Search for dissertations about: "Islet function"

Showing result 21 - 25 of 123 swedish dissertations containing the words Islet function.

  2. 21. Implantation-Site Dependent Differences in Engraftment and Function of Transplanted Pancreatic Islets

    Author : Joey Lau; Per-Ola Carlsson; Leif Jansson; Carina Carlsson; Caroline Kampf; Annika Tibell; Uppsala universitet; []
    Keywords : Cell biology; Type 1 diabetes; pancreatic islets; human islets; islet transplantation; vascular engraftment; revascularization; implantation-site; microenvironment; vascular density; insulin release; pro insulin biosynthesis; glucose oxidation; Cellbiologi;

    Abstract : Transplanting pancreatic islets into the liver through the portal vein is currently the most common procedure in clinical islet transplantations for treating patients with brittle type 1 diabetes. However, most islet grafts fail within a 5-year period necessitating retransplantation. READ MORE

  4. 22. Role of Islet Endothelial Cells in β-cell Function and Growth

    Author : Magnus Johansson; Leif Jansson; Per-Ola Carlsson; Lena Holm; Susan Bonner-Weir; Uppsala universitet; []
    Keywords : Cell biology; Cellbiologi;

    Abstract : The pancreatic islets are collections of endocrine cells, dispersed throughout the pancreas. In adult islets, endocrine cells are closely associated with capillary endothelial cells and receive a high blood perfusion. Transplanted pancreatic islets, on the other hand, have a vascular disturbance, manifested as decreased blood vessel density. READ MORE

  5. 23. Ghrelin and CART. Two new islet peptides. Expression, regulation and function

    Author : Nils Wierup; Institutionen för experimentell medicinsk vetenskap; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Endokrinologi; sekretion; diabetologi; Endocrinology; secreting systems; diabetology; histology; endocrinology; islets; CART; Ghrelin cells; insulin secretion; type-2 diabetes; Ghrelin;

    Abstract : Until recently, the islets of Langerhans were thought to harbour four main cell types characterised with respect to principal hormone product. Here we show that the novel hormone ghrelin is expressed in a fifth islet cell type, the islet ghrelin cell, in humans and rodents. READ MORE

  6. 24. Studies of the human pancreas to understand the pathologic events leading to type 1 diabetes

    Author : Louise Granlund; Skog Oskar; Olle Korsgren; Marcus Lundberg; Per Andrén; Teresa Rodriguez-Calvo; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pancreas; Type 1 Diabetes; Islets of Langerhans; Exocrine tissue; Acinar cells; Islet Microvasculature; Endocrine cells; Extra-islet cells; Insulin; Glucagon; Medicinsk vetenskap; Medical Science;

    Abstract : Type 1 diabetes (T1D) is classically described as a disease emanating from beta-cell loss, and as such, the beta cells have been the main target of investigation. However, recent years have witnessed a shift in perspective, with T1D being increasingly recognized as a condition that affects the entire pancreas. READ MORE

  7. 25. Receptor-operated signaling pathways in normal and diabetic pancreatic islet cell function

    Author : Fan Zhang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Loss of glucose-dependent insulin release is an early pathogenetic event in human type 2 diabetes. Impaired glucose-mediated insulin secretion from pancreatic islet β-cells leads to insulin deficiency and thus hyperglycemia. READ MORE