Search for dissertations about: "Islet of the Langerhans"

Showing result 1 - 5 of 74 swedish dissertations containing the words Islet of the Langerhans.

  2. 1. Pancreatic Islet Transplantation : Modifications of Islet Properties to Improve Graft Survival

    Author : Sanja Cabric; Olle Korsgren; Bo Nilsson; Peetra Magnusson; Michael Breimer; Uppsala universitet; []
    Keywords : Medicine; Diabetes; islet transplantation; islets of Langerhans; coagulation activation; IBMIR; hirudin; heparin; growth factor; angiogenesis; Medicin;

    Abstract : During the past decade clinical islet transplantation has become a viable strategy for curing type 1 diabetes. The limited supply of organs, together with the requirement for islets from multiple donors to achieve insulin independence, has greatly limited the application of this approach. READ MORE

  4. 2. The Role of Innate Immunity in Islet Transplantation : Clinical and Experimental Studies

    Author : Lisa Moberg; Bo Nilsson; Olle Korsgren; Kristina Nilsson Ekdahl; Rolf Larsson; David Harlan; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; diabetes; islet transplantation; islet of Langerhans; coagulation activation; IBMIR; tissue factor; thrombin; inactivated FVIIa; melagatran; neutrophilic granulocyte; Immunologi; Immunology; Immunologi;

    Abstract : Clinical islet transplantation is an emerging procedure to cure type 1 diabetes. The graft is implanted by infusion into the liver through the portal vein. A major obstacle that still needs to be overcome is the requirement for islets from multiple donors to achieve insulin independence. READ MORE

  5. 3. Islet Xenotransplantation : An Experimental Study of Barriers to Clinical Transplantation

    Author : Peter Schmidt; Olle Korsgren; Bo Nilsson; Karin Ulrichs; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; xenotransplantation; islets of Langerhans; rejection; diabetes; porcine endogenous retroviruses; quantitative RT-PCR; cytokines; animal models; Medicin; Dermatology and venerology; clinical genetics; internal medicine; Dermatologi och venerologi; klinisk genetik; invärtesmedicin;

    Abstract : In the field of transplantation, the increasing deficit of human donors have lead to an interest in animals as an alternative source of organs and tissues. Different in vitro systems and rodent models of xenotransplantation were used to examine the most significant barriers that have to be overcome, before isolated islets of Langerhans from pigs can be used as a cure for insulin-dependent diabetes mellitus in humans. READ MORE

  6. 4. Formation of Composite Islet Grafts : A novel strategy to promote islet survival and revascularization

    Author : Ulrika Johansson; Peetra Magnusson; Korsgren Olle; Bo Nilsson; Federico Bertuzzi; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Islet of Langerhans; cytokines and cytokinereceptors expression; endothelial cells; mesenchymal stromal cells; transplantation; revascularization; Clinical immunology; Klinisk immunologi; cellforskning; cellforskning;

    Abstract : The islets of Langerhans are small and delicate spheroid organs scattered in the pancreas responsible for insulin production. Transplantation of isolated islets is a beneficial therapy for patients with a severe form of type 1 diabetes. READ MORE

  7. 5. Imaging Islets of Langerhans by Positron Emission Tomography : Quantification of Beta-Cell Mass in the Native Pancreas and the Islet Graft

    Author : Olof Eriksson; Anders Sundin; Olle Korsgren; Bengt Långström; Bo Nilsson; Håkan Ahlström; Habib Zaidi; Uppsala universitet; []
    Keywords : Positron Emission Tomography; [18F]FDG; dihydrotetrabenazine; Islet transplantation; IBMIR; beta-cell mass; MEDICINE; MEDICIN;

    Abstract : Type 1 and 2 Diabetes Mellitus are a growing health problem throughout the world. There is an increasing  need for methodologies, which are both reliable and non-invasive to measure the amount of insulin-producing tissue (Beta-cell mass, or BCM), as well as rapidly quantify changes in the BCM due to the onset of disease, beta-cell replacement therapy, or other treatments. READ MORE