Search for dissertations about: "Islets of Langerhans : physiology"

Showing result 1 - 5 of 7 swedish dissertations containing the words Islets of Langerhans : physiology.

2. 1. Physiological Studies of Native and Stem Cell-Derived Islets

   Author : Daniel Norman; Per-Ola Carlsson; Daniel Espes; Helge Ræder; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Irisin; CART; Islet blood flow; Islets of Langerhans; Stem cell-derived islets; Fysiologi; Physiology; Medical Cell Biology; Medicinsk cellbiologi;

   Abstract : In type 1 and type 2 diabetes, the β-cells of the islets of Langerhans are either destroyed by the immune system or stressed due to peripheral insulin resistance. To improve the life of patients with these diseases, new treatments are needed. READ MORE

4. 2. Leukocytes in Angiogenesis : Learning from Transplanted Pancreatic Islets

   Author : Gustaf Christoffersson; Mia Phillipson; Kristian Pietras; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; angiogenesis; pancreatic islet transplantation; islets of Langerhans; diabetes mellitus; leukocytes; neutrophils; macrophages; pericytes; MMP-9; VEGF-A; Medical Science; Medicinsk vetenskap;

   Abstract : Angiogenesis, the growth of new blood vessels, is a complex process involving several cell types and molecular signals. Excessive vascular growth is a problem in tumors, and insufficient vascularization hampers the function of transplanted insulin-producing pancreatic islets. READ MORE

5. 3. Electrophysiology of pancreatic A-, B- and D-cells studied in intact mouse islets of Langerhans

   Author : Sven Göpel; Institutionen för experimentell medicinsk vetenskap; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; somatostatin; glucagon; insulin; patch-clamp; membrane potential; Pancreatic islet; ion channel; diabetes; Physiology; Fysiologi;

   Abstract : Abstract The electrophysiological properties of insulin-secreting b-cells, glucagon-releasing a-cells and somatostation-producing d-cells in intact mouse pancreatic islets were investigated using the perforated patch whole-cell technique. It is demonstrated that it is possible to functionally identify the different cell types in situ. READ MORE

6. 4. Quantification of gene expression in single cells

   Author : Martin Bengtsson; Islet cell physiology; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicin människa och djur ; Medicine human and vertebrates ; Biomedical sciences; Biomedicinska vetenskaper; quantitative gene expression analysis; single cell PCR; islets of Langerhans;

   Abstract : Studies of apparently homogeneous cell populations and single cells often give highly divergent results. Cells exhibit varying responsiveness to stimuli and gene expression and they are in many aspects stochastic and unpredictable. We have developed a method to measure gene expression quantitatively in individual cells with real-time RT-PCR. READ MORE

7. 5. Physiology and Pathophysiology of Hormone Secretion from lslets of Langerhans

   Author : Samuel Acreman; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Islet; diabetes; glucagon; insulin; somatostatin; incretin; pancreas; hypoglycaemia; tetraspanin; GLP-1; endoplasmic reticulum;

   Abstract : Diabetes is a metabolic disorder stemming from the improper regulation of blood glucose levels by hormones secreted by pancreatic islets of Langerhans. Paper I describes the mechanism by which glucose can regulate glucagon secretion, independent of membrane potential, from pancreatic α-cells, via modulation of endoplasmic reticulum Ca2+ handling. READ MORE