Search for dissertations about: "Islets of Langerhans"

Showing result 16 - 20 of 107 swedish dissertations containing the words Islets of Langerhans.

  2. 16. Effects of Enterovirus Infection on Innate Immunity and Beta Cell Function in Human Islets of Langerhans

    Author : Oskar Skog; Gun Frisk; Olle Korsgren; Åke Lernmark; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 1 diabetes; Enterovirus; Coxsackievirus; Innate immunity; Pancreatic islets; Islet function; Medicinsk vetenskap; Medical Science;

    Abstract : This thesis focuses on enteroviral effects on human pancreatic islets. Most knowledge of viral effects on host cells relies on studies of immortalized cell lines or animal models. The islets represent a fundamentally different and less well studied cellular host. Also, enterovirus has been implicated in the etiology of type 1 diabetes (T1D). READ MORE

  4. 17. Islet Xenotransplantation : An Experimental Study of Barriers to Clinical Transplantation

    Author : Peter Schmidt; Olle Korsgren; Bo Nilsson; Karin Ulrichs; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; xenotransplantation; islets of Langerhans; rejection; diabetes; porcine endogenous retroviruses; quantitative RT-PCR; cytokines; animal models; Medicin; Dermatology and venerology; clinical genetics; internal medicine; Dermatologi och venerologi; klinisk genetik; invärtesmedicin;

    Abstract : In the field of transplantation, the increasing deficit of human donors have lead to an interest in animals as an alternative source of organs and tissues. Different in vitro systems and rodent models of xenotransplantation were used to examine the most significant barriers that have to be overcome, before isolated islets of Langerhans from pigs can be used as a cure for insulin-dependent diabetes mellitus in humans. READ MORE

  5. 18. Immunopathology of the Pancreas in Type 1 Diabetes

    Author : Anna Wiberg; Olle Korsgren; Oskar Skog; Åke Lernmark; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 1 diabetes; glucagon; T cells; autoantibodies; glucose transporters; islets of Langerhans; pancreas; Klinisk immunologi; Clinical Immunology;

    Abstract : Type 1 diabetes (T1D) results from a loss of functional insulin-producing pancreatic beta cells. The etiology of T1D is poorly understood, but the detection of infiltrating inflammatory cells in the pancreas and circulating autoantibodies has led to the common notion that an autoimmune process plays a central role in the pathogenesis of the disease. READ MORE

  6. 19. Pancreatic Islet Transplantation : Modifications of Islet Properties to Improve Graft Survival

    Author : Sanja Cabric; Olle Korsgren; Bo Nilsson; Peetra Magnusson; Michael Breimer; Uppsala universitet; []
    Keywords : Medicine; Diabetes; islet transplantation; islets of Langerhans; coagulation activation; IBMIR; hirudin; heparin; growth factor; angiogenesis; Medicin;

    Abstract : During the past decade clinical islet transplantation has become a viable strategy for curing type 1 diabetes. The limited supply of organs, together with the requirement for islets from multiple donors to achieve insulin independence, has greatly limited the application of this approach. READ MORE

  7. 20. Quantification of gene expression in single cells

    Author : Martin Bengtsson; Islet cell physiology; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicin människa och djur ; Medicine human and vertebrates ; Biomedical sciences; Biomedicinska vetenskaper; quantitative gene expression analysis; single cell PCR; islets of Langerhans;

    Abstract : Studies of apparently homogeneous cell populations and single cells often give highly divergent results. Cells exhibit varying responsiveness to stimuli and gene expression and they are in many aspects stochastic and unpredictable. We have developed a method to measure gene expression quantitatively in individual cells with real-time RT-PCR. READ MORE