Search for dissertations about: "Isolated regional perfusion"

Found 5 swedish dissertations containing the words Isolated regional perfusion.

2. 1. Immunological effects of isolated regional perfusion in malignant melanoma

   Author : Junko Johansson; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Melanoma; Isolated regional perfusion; ILP; IHP; Melphalan; Immunogenic cell death; T cells; Monocytes; ISG;

   Abstract : Malignant melanoma patients with metastatic disease confined to the limbs or liver may be treated with hyperthermic isolated regional perfusion with a chemotherapeutic agent, most commonly melphalan. This procedure enables much higher tissue concentrations of the chemotherapeutic agent compared with systemic administration. READ MORE

4. 2. Isolated regional perfusion for metastases of malignant melanoma - Clinical and experimental studies

   Author : Roger Olofsson; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Malignant melanoma; Uveal melanoma; Isolated limb perfusion; Isolated hepatic perfusion; Immunology; Exosomes;

   Abstract : Background: Isolated regional perfusion is a treatment option mainly for localized metastatic disease. The principle idea is to surgically isolate a region of the body and connect the circulation to a heart-lung machine. A high concentration of a chemotherapeutic agent is then delivered to the tumour, while systemic toxicity is avoided. READ MORE

5. 3. Regional pulmonary vasoreactivity, with special reference to nitric oxide, prostacyclin and body posture

   Author : Danguolé Rimeika; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Regional pulmonary perfusion; nitric oxide; prostacyclin; NOS-inhibition; COX-inhibition; shunt; one-lung ventilation;

   Abstract : The primary aim of the study was to investigate possible mechanisms behind the improved arterial oxygenation in ventilator-treated patients with acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) when turned into prone position. A secondary aim was to discover new knowledge of possible importance for treatment of patients with oxygenation problems in intensive care and during anesthesia. READ MORE

6. 4. Local Purinergic Control of Arteriolar Reactivity in Pancreatic Islets and Renal Glomeruli

   Author : Xiang Gao; Leif Jansson; Olle Hellberg; Uppsala universitet; []
   Keywords : afferent arteriole; islet arteriole; adenosine; A1 receptor; ATP; P2Y receptor; microperfusion; angiotensin II; type 2 diabetes; hypertension; oxidative stress; nitric oxide; tubuloglomerular feedback;

   Abstract : Local control of regional blood flow is exerted mainly through the arterioles. An adequate minute-to-minute regulation of blood perfusion of the kidney and the pancreas is obtained by the modulation of arteriolar reactivity, which will influence the organ function. READ MORE

7. 5. Transport and metabolism of opioid tetrapeptide agonists with a focus on oral and respiratory delivery

   Author : Eva Krondahl; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; opioid peptides; permeability; metabolism; oral delivery; pulmonary delivery; FARMACI; PHARMACY; FARMACI; galenisk farmaci; Pharmaceutics;

   Abstract : The clinical development of peptide drugs for oral delivery has often been hindered because of poor transport across the intestinal membranes and degradation in the gastrointestinal tract and liver. Alternative delivery routes through more permeable membranes preferably with less pronounced proteolytic activity, such as the nasal and pulmonary routes, have therefore been considered. READ MORE