Search for dissertations about: "Ivan Dikic"

Found 3 swedish dissertations containing the words Ivan Dikic.

  2. 1. Ubiquitination and Receptor Endocytosis

    Author : Kaisa Haglund; Carl-Henrik Heldin; Ivan Dikic; Harald Stenmark; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; Ubiquitination; receptor tyrosine kinase; endocytosis; Cbl; CIN85; EGFR; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi;

    Abstract : Protein ubiquitination is an evolutionary conserved mechanism that controls a wide variety of cellular functions. Polyubiquitinated proteins are generally degraded in the proteasome, whereas monoubiquitination controls various other cellular processes, including endocytosis and endosomal sorting. READ MORE

  4. 2. Adaptor Proteins in Regulation of Receptor Endocytosis

    Author : Katarzyna Kowanetz; Carl-Henrik Heldin; Ivan Dikic; Ruth Palmer; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi;

    Abstract : Ligand-induced endocytosis of receptor tyrosine kinases (RTKs) is a dynamic process governed by numerous protein-protein and protein-lipid interactions. This is a major mechanism of signal termination and is also frequently impaired in cancer. READ MORE

  5. 3. Cbl in Regulation of Growth Factor Receptor Endocytosis and Actin Dynamics

    Author : Iwona Szymkiewicz; Ivan Dikic; Silvia Giordano; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; RTK; Cbl; endocytosis; ubiquitination; actin; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi; Molekylär cellbiologi; Molecular Cellbiology;

    Abstract : Proteins belonging to the Cbl family are multidomain scaffolds that participate in numerous processes, assembling signaling complexes and mediating attachment of ubiquitin to receptor and non-receptor tyrosine kinases.We characterized a novel role for Cbl and Cbl-b in ligand-dependent internalization of growth factor receptors. READ MORE