Search for dissertations about: "J3D"

Found 5 swedish dissertations containing the word J3D.

  2. 1. The antagonistic role of activated oncogenes and apoptosis : studies of n-myc and p53 in lymphoid tumorigenesis

    Author : Yisong Wang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MPC; EmyN-myc transgene; J3D T Iymphoma cells; p53; v-m y cretrovirus; bcl-2; Gl cell cycle arrest; apoptosis; HPV 16 E7;

    Abstract : Inactivation of the p53 tumor suppressor gene and activation of proto-oncogenes have been implicated in the initiation and/or progression of a number of neoplasms. In this thesis, the involvement of N-myc gene activation has been studied in mouse plasmacytomagenesis and the role of wild-type (wt)p53 and oncogene activation has been evaluated with particular emphasis on apoptosis. READ MORE

  4. 2. p53 functional loss by mutation and p53 antagonizing proteins during tumor development

    Author : Qian Wang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : p53 is the most common target for genetic alterations in human cancers. Inactivation of wild type p53 function by point mutation, deletion or complexing with antagonizing proteins such as MDM2 and DNA tumor viral oncoproteins, is frequently found in human and rodent tumors. READ MORE

  5. 3. Cloning and characterization of a p-53-inducible gene, WIG-1

    Author : Shohreh Varmeh-Ziaie; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Elucidating the mechanisms by which p53 inhibits tumor growth is a central issue in cancer research, as the TP53 gene is mutated in over half of all human cancers. Lack of functional p53 also contributes to the resistance of many tumor types to chemotherapy and radiotherapy. READ MORE

  6. 4. Molecular studies of Wig-1, a p53-induced zinc finger protein

    Author : Cristina Méndez Vidal; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The fact that p53 is one of the most commonly mutated gene in human tumors indicates that it has a key role in tumor suppression. p53 accumulates after DNA-damage and other types of cellular stress, leading to the initiation of a p53-dependent biological response, including cell cycle arrest and apoptosis. READ MORE

  7. 5. The p53-induced Wig-1 protein : studies of interaction partners and expression in tumor cells

    Author : Magdalena Prahl; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The tumor suppressor p53 is a critical regulator of life and death in cells. The p53 protein is present at very low levels in cells under normal conditions but accumulates in response to different stress stimuli, such as DNA damage, hypoxia, and oncogene activation. READ MORE