Search for dissertations about: "JNK kinases"
Showing result 1 - 5 of 21 swedish dissertations containing the words JNK kinases.
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1. The role of protein kinases in development and disease
Abstract : .... READ MORE
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2. MEKK-1 and NF-κB Signaling in Pancreatic Islet Cell Death
Abstract : Type 1 diabetes is an autoimmune disease resulting in the selective destruction of the insulin producing β-cells in the pancreas. Pro-inflammatory cytokines and the free radical nitric oxide (NO) have been implicated in mediating the destruction of β-cells, possibly through activation of the mitogen activated protein kinases (MAPKs) JNK, ERK and p38. READ MORE
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3. Signal Transduction in Focal Cerebral Ischemia : Experimental Studies on VEGF, MAPK and Src family kinases
Abstract : Cerebral ischemia elicits a wide range of events, including complex activation of various intracellular signaling pathways. This study aims to investigate the expression of vascular endothelial growth factor (VEGF) and the activation pattern of mitogen-activated protein kinases (MAPK) in reponse to focal cerebral ischemia. READ MORE
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4. Role of MAP Kinases in the Life and Death of Beta-cells
Abstract : The development of diabetes mellitus depends on the balance between beta-cell proliferation and death. As mitogen-activated protein kinases (MAPK) may control this balance, the aim of this study was to investigate the events leading to MAPK activation in beta-cells and the consequences of these events. READ MORE
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5. On the role of SAP kinase pathways in cellular responses to cancer treatment
Abstract : Inherited or acquired resistance to therapy is a major clinical problem in the treatment of cancer. Defective apoptosis signalling is increasingly acknowledged as an important mechanism of resistance. Better understanding of apoptosis regulation may therefore help improve therapy. READ MORE