Search for dissertations about: "JNK"

Showing result 16 - 20 of 91 swedish dissertations containing the word JNK.

  2. 16. Transcriptional patterns in inflammatory disease

    Author : Johan Lindberg; Joakim Lundeberg; Eivind Hovig; KTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Gene expression profiling; transcription; microarray; rheumatoid arthritis; synovial tissue; variability; TNF‐α; anti‐TNF treatment; periodontitis; PGE2; Bioengineering; Bioteknik;

    Abstract : In the studies this thesis is based upon, microarrays were applied to profilemRNA populations in biological samples to gain insights into transcriptionalpatterns and their relation to inflammatory disease.Rheumatoid arthritis (RA) is a chronic inflammatory disease, which leads todegradation of cartilage and bone. READ MORE

  4. 17. Signalomics : unsupervised and global strategies to explore mechanisms of radioresistence in lung cancer cells

    Author : Sara Ståhl; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : To combat lung cancer (LC) which is the number one cancer associated killer, a combination of surgery, chemotherapy, radiotherapy and targeted agents are currently used. The main subtype of LC, Non small cell lung cancer (NSCLC) unfortunately responds poorly to conventional radiotherapy (RT) for reasons yet only partly understood. READ MORE

  5. 18. Stress and immune signaling in a Drosophila tumor model

    Author : Dilan Khalili; Ulrich Theopold; Mirka Uhlirova; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Drosophila; cancer; innate immunity; fibrosis; antimicrobial peptides; chitinase-like proteins; molekylär biovetenskap; Molecular Bioscience;

    Abstract : Cancer cells contain multiple biological alterations that allow them to escape from host surveillance mechanisms. One of the mechanisms that play an essential role in host protection against tumor growth is immunity. READ MORE

  6. 19. Signaling and transcriptional regulation of antimicrobial peptide genes in Drosophila melanogaster

    Author : Hanna Uvell; Ylva Engström; Won-Jae Lee; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; antimicrobial peptides; drosophila; immunity; transcriptiona regulation; Molecular biology; Molekylärbiologi;

    Abstract : Insects rely solely on innate immune reactions for protection against infect-ing microbes in their environment. In Drosophila, one major defense mechanism is the production of a battery of antimicrobial peptides (AMPs). READ MORE

  7. 20. Cytokine induced airway hyperreactivity characterized in an in-vitro model of asthma

    Author : Yaping Zhang; Klinisk och experimentell allergiforskning; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; toxicology; Farmakologi; farmakognosi; MAPK; TNF-alpha; 5-HT; Respiratory system; Andningsorganen; Pharmacological sciences; pharmacognosy; pharmacy; interleukin-1beta; hyperresponsiveness; endothelin-1; airway; bradykinin; toxikologi; farmaci;

    Abstract : Asthma is a chronic disorder of the lower airways, characterized by inflammation and hyperreactivity. Pro-inflammatory cytokines like tumour necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) are known to play important roles in the pathogenesis, but our knowledge how these cytokines contribute to the development of airway hyperreactivity is limited. READ MORE