Search for dissertations about: "JNK"

Showing result 6 - 10 of 91 swedish dissertations containing the word JNK.

  2. 6. Development of a New Biomechanical ex vivo Perfusion System - Studies on effects of biomechanical and inflammatory stress on hemostatic genes in human vascular endothelium

    Author : Niklas Bergh; Göteborgs universitet; []
    Keywords : ex vivo perfusion system; biomechanical; endothelium; shear stress; tensile stress; pulsatile; TNF-α; JNK; hemostatic genes;

    Abstract : The vascular endothelium is a multifunctional interface constantly exposed to biomechanical forces such as shear and tensile stress. Biomechanical stress is involved in the pathophysiological process of the vessel wall and thus affects vascular remodeling, atherosclerosis and thrombogenesis. READ MORE

  4. 7. Function and targets of the Urm1/Uba4 conjugation machinery in Drosophila melanogaster

    Author : Behzad Khoshnood; Caroline Grabbe; Tor Erik Rusten; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Drosophila; Urm1; Uba4; MOCS3; Tax; HTLV; Posttranslational modification; ubiquitin-like modifiers; UBL; PTM; JNK; neuromuscular junctions; signaling; molekylärbiologi; Molecular Biology;

    Abstract : Posttranslational modification (PTM) of proteins is essential to maintain homeostasis and viability in all eukaryotic cells. Hence, besides the sequence and 3D folding of a polypeptide, modification by multiple types of PTMs, ranging from small molecular groups to entire protein modules, adds another layer of complexity to protein function and regulation. READ MORE

  5. 8. The role of protein kinases in development and disease

    Author : Renée Daams; Avdelningen för translationell cancerforskning; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Nemo-like kinase NLK ; JNK kinases; T-Cell; Lung Cancer; Colorectal cancer CRC ; Cell signaling;

    Abstract : .... READ MORE

  6. 9. Cell interactions in the CNS and their consequences for neuronal apoptosis

    Author : Mikaela Berglund; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Aggregate cultures; apoptosis; automated image analysis; cytochrome c; interactions; JNK; microglia; neuron; neural precursor cells; rotenone; UV.;

    Abstract : The central nervous system consists of an intricate network of neurons and glial cells that depend on reciprocal communication to develop and maintain the vital functions of the brain. if the balance is disturbed by injury or disease, two cell types in particular, microglia and astrocytes, respond by producing factors that help combat the infection or delimit the affected area. READ MORE

  7. 10. Proinsulin C-peptide : membrane interactions and intracellular signaling

    Author : Zhihui Zhong; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Human renal tubular cell; intracellular signal transduction; ERK1 2; JNK; Na ; K -A TPase; G-protein coupled receptor.;

    Abstract : In the past decade, new evidence has emerged of a physiological role for C-peptide. C-peptide replacement improves renal and nerve function and augments regional blood flow in type I diabetic patients. READ MORE