Search for dissertations about: "Jan Komorowski"
Showing result 6 - 10 of 20 swedish dissertations containing the words Jan Komorowski.
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6. Predictive Healthcare : Cervical Cancer Screening Risk Stratification and Genetic Disease Markers
Abstract : The use of Machine Learning is rapidly expanding into previously uncharted waters. In the medicine fields there are vast troves of data available from hospitals, biobanks and registries that now are being explored due to the tremendous advancement in computer science and its related hardware. READ MORE
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7. Bioinformatic identification of disease associated pathways by network based analysis
Abstract : Many common diseases are complex, meaning that they are caused by many interacting genes. This makes them difficult to study; to determine disease mechanisms, disease-associated genes must be analyzed in combination. READ MORE
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8. Rule-based Models of Transcriptional Regulation and Complex Diseases : Applications and Development
Abstract : As we gain increased understanding of genetic disorders and gene regulation more focus has turned towards complex interactions. Combinations of genes or gene and environmental factors have been suggested to explain the missing heritability behind complex diseases. READ MORE
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9. Integrating multi-omics for type 2 diabetes : Data science and big data towards personalized medicine
Abstract : Type 2 diabetes (T2D) is a complex metabolic disease characterized by multi-tissue insulin resistance and failure of the pancreatic β-cells to secrete sufficient amounts of insulin. Cells recruit transcription factors (TF) to specific genomic loci to regulate gene expression that consequently affects the protein and metabolite abundancies. READ MORE
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10. The Nucleosome as a Signal Carrying Unit : From Experimental Data to Combinatorial Models of Transcriptional Control
Abstract : The human genome consists of over 3 billion nucleotides and would be around 2 meters long if uncoiled and laid out. Each human somatic cell contains all this in their nucleus which is only around 5 µm across. This extreme compaction is largely achieved by wrapping the DNA around a histone octamer, the nucleosome. READ MORE