Search for dissertations about: "Jeanette Hellgren Kotaleski"

Showing result 1 - 5 of 14 swedish dissertations containing the words Jeanette Hellgren Kotaleski.

  2. 1. Modeling of bursting mechanisms and coordination in a spinal central pattern generator

    Author : Jeanette Hellgren Kotaleski; KTH; []
    Keywords : adaptation; central pattern generator; computer simulation; inter segmental coordination; lamprey; locomotion; neural network; rhythmogenesis; TECHNOLOGY; TEKNIKVETENSKAP;

    Abstract : Mechanisms underlying lotal bursting as well as coordinationbetween different levels of a spinal CPG generating locomotionhave been investigated using computer simulations. A"primitive" jawless vertebrate, the lamprey, is used a.s aprototype model. READ MORE

  4. 2. Untangling Cortico-Striatal Circuitry and its Role in Health and Disease - A computational investigation

    Author : Jovana Belic; Jeanette Hellgren Kotaleski; Arvind Kumar; Abigail Morrison; Arthur Leblois; KTH; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cortico-striatal circuits; levodopa-induced dyskinesia; Parkinson’s disease; effective connectivity; cross-frequency coupling; corticostriatal network; network oscillations; GABAergic transmission. basal ganglia; striatum; cortex; fast spiking interneurons; medium spiny neurons; neuronal avalanches;

    Abstract : The basal ganglia (BG) play a critical role in a variety of regular motor and cognitive functions. Many brain diseases, such as Parkinson’s diseases, Huntington’s disease and dyskinesia, are directly related to malfunctions of the BG nuclei. READ MORE

  5. 3. Method development for co-simulation of electrical-chemical systems in Neuroscience

    Author : Ekaterina Brocke; Jeanette Hellgren Kotaleski; Gaute Einevoll; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; multiscale; multirate; co-simulation; electrical-chemical; Computer Science; Datalogi;

    Abstract : Multiscale modeling and simulation is a powerful approach for studying such phenomena in nature as learning and memory. In computational neuroscience, historically, methods and tools for neuronal modeling and simulations have been developed for studies focused on a single level of the neuronal organization. READ MORE

  6. 4. Computational Modelling and Topological Analysis of the striatal microcircuitry in health and Parkinson's disease

    Author : Ilaria Carannante; Jeanette Hellgren Kotaleski; Alexander Kozlov; Sean Hill; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Datalogi; Computer Science;

    Abstract : The basal ganglia are evolutionary conserved nuclei located at the base of the forebrain. They are a central hub in the control of motion and their dysfunctions lead to a variety of movement related disorders, including Parkinson's disease (PD).The largest nucleus and main input stage of the basal ganglia is the striatum. READ MORE

  7. 5. Characterisation of inputs and outputs of striatal medium spiny neurons in health and disease

    Author : Marko Filipović; Jeanette Hellgren Kotaleski; Arvind Kumar; Gilad Silberberg; Ad Aertsen; Andrew Sharott; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; basal ganglia; striatum; medium spiny neurons; subthalamic nucleus; globus pallidus; Parkinson s disease; in vivo; oscillations; spectral analysis; response variability; networks; simulations; modelling; Numerical Analysis; Numerisk analys; Computer Science; Datalogi; Biological and Biomedical Physics; Biologisk och biomedicinsk fysik;

    Abstract : Striatal medium spiny neurons (MSNs) play a crucial role in various motor and cognitive functions. They are separated into those belonging to the direct pathway (dMSNs) and the indirect pathway (iMSNs) of the basal ganglia, depending on whether they express D1 or D2 type dopamine receptors, respectively. READ MORE