Search for dissertations about: "Jeremy"

Showing result 1 - 5 of 32 swedish dissertations containing the word Jeremy.

  2. 1. Characterizing and exploiting the endocytic pathway for macromulecular delivery

    Author : Jeremy Bost; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Macromolecular drugs with cytosolic or nuclear targets often exhibit low therapeutic activity due, at least in part, to their inability to escape endosomal compartments following cellular internalization. There exist a range of strategies to address this inefficient delivery by attempting to bolster the endosomal escape of the therapeutic cargo. READ MORE

  4. 2. Evidence by interaction : a new role of caspase-2

    Author : Jeremy Forsberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Caspase-2 is the best conserved member of the caspase family. Although being known to mediate cell death following DNA damage, many studies have implicated that this protease regulates a variety of cellular processes. Despite this, few well-defined and mechanistically explained functions of caspase-2 has been described. READ MORE

  5. 3. Mutant p53 reactivation by prima-1 : molecular mechanism and biological effects

    Author : Jérémy Lambert; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cancer has become one of the leading causes of death worldwide. It is now clear that tumors arise due to the malfunction of a number of genes, thus emphasising the importance of targeted therapies directed to crucial types of genetic alterations. READ MORE

  6. 4. On mapping the human somatosensory cortex : fMRI and PET imaging

    Author : Jeremy Young; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Mapping; anatomy; connectivity; somatosensory; attention; organisation; somatotopy; fMRI; PET; rCBF; cytoarchitecture.;

    Abstract : This work is based on experiments and simulations for the purpose of mapping the human somatosensory cortex. By using a combination of structural mapping (cytoarchitecture), connectivity mapping, functional mapping, and somatotopical mapping an overview of the organisation of the human somatosensory cortex at different levels is possible. READ MORE

  7. 5. Designing a Functional Programming Architecture for the Internet of Things

    Author : Jeremy Pope; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; High-Level Synthesis; internet of things; Hardware description languages; Architectures; Functional Programming;

    Abstract : As the Internet of Things (IoT) grows, so too do security concerns: as well as typically having access to sensors and actuators, IoT devices are often programmed using bug-prone, low-level languages. Such a combination results in vulnerabilities that pose risks to privacy and safety. READ MORE