Search for dissertations about: "Jiawei Zhu"

Found 1 swedish dissertation containing the words Jiawei Zhu.

  1. 1. p53-dependent and -independent mechanisms of p53-targeting small molecules

    Author : Jiawei Zhu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : Tumor suppressor p53 (Tp53) is mutated in around half of human cancers, while in wild type p53 cells its activity is continuously inhibited by MDM2 through proteasome degradation resulting in the loss of its function. Currently, cancer treatments with small molecules based on reactivation of wild type p53 and restoration of mutant p53 have moved to clinical trials and exhibited promising anti-cancer effects. READ MORE