Search for dissertations about: "Joakim Lundeberg"

Showing result 21 - 25 of 41 swedish dissertations containing the words Joakim Lundeberg.

  2. 21. Transcriptional patterns in inflammatory disease

    Author : Johan Lindberg; Joakim Lundeberg; Eivind Hovig; KTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Gene expression profiling; transcription; microarray; rheumatoid arthritis; synovial tissue; variability; TNF‐α; anti‐TNF treatment; periodontitis; PGE2; Bioengineering; Bioteknik;

    Abstract : In the studies this thesis is based upon, microarrays were applied to profilemRNA populations in biological samples to gain insights into transcriptionalpatterns and their relation to inflammatory disease.Rheumatoid arthritis (RA) is a chronic inflammatory disease, which leads todegradation of cartilage and bone. READ MORE

  4. 22. Methods to Prepare DNA for Efficient Massive Sequencing

    Author : Sverker Lundin; Joakim Lundeberg; Harold Swerdlow; KTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DNA; Massive sequencing; Next Generation Sequencing; Library Preparation; Barcoding; Multiplexing;

    Abstract : Massive sequencing has transformed the field of genome biology due to the continuous introduction and evolution of new methods. In recent years, the technologies available to read through genomes have undergone an unprecedented rate of development in terms of cost-reduction. READ MORE

  5. 23. Spatial mapping of bacteria and transcriptomes

    Author : Britta Lötstedt; Joakim Lundeberg; Anders F. Andersson; Petri Auvinen; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; spatial transcriptomics; 16S sequencing; antibody-based measurements; spatiell transkriptomik; 16S-sekvensering; antikroppsbaserade mätningar; Biotechnology; Bioteknologi;

    Abstract : Novel insights into biological functions and mechanisms, cell networks and evolutionary relationships are gained through development of sequencing technologies and sequencing based applications. Massively parallel sequencing has enabled analysis of big data at gene and protein expression levels, but has also characterized bacterial communities. READ MORE

  6. 24. Towards spatial host-microbiome profiling

    Author : Britta Lötstedt; Joakim Lundeberg; Petri Auvinen; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; 16S sequencing; RNA sequencing; spatially resolved transcriptomics; antibody-based measurements; Bioteknologi; Biotechnology;

    Abstract : Sequencing technologies and applications have pushed the limits and enabled novel studies of biological mechanisms, evolutionary relationships and communication networks between cells. The technical developments leading to single cell RNA-sequencing have enabled detection of rare cell populations while spatial resolution added insights into larger biological environments, like tissues and organs. READ MORE

  7. 25. Spatial transcriptome and epigenome analysis with focus on prostate cancer

    Author : Maja Marklund; Joakim Lundeberg; Patrik Ståhl; Marc Friedländer; KTH; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Spatial; Spatial Transcriptomics; Spatial ATAC; epigenomics; Biotechnology; Bioteknologi;

    Abstract : Each cancer is unique, and therefore the use of general treatments are often suboptimal. If we can understand the mechanisms of cancer development, we might be able to develop effective treatments tailored to each patient. Our bodies are complex three-dimensional structures and how things are organized correlate with proper functioning. READ MORE