Search for dissertations about: "Johan Danielson"

Found 3 swedish dissertations containing the words Johan Danielson.

  2. 1. Anorectal Malformations : Long-term outcome and aspects of secondary treatment

    Author : Johan Danielson; Wilhelm Graf; Urban Karlbom; Tomas Wester; Olof Hallböök; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; anorectal malformation; faecal incontinence; long-term outcome; Krickenbeck; NASHA Dx;

    Abstract : Faecal incontinence (FI) is defined as the inability to control bowel movements. The causes of FI are many and diverse. One of the more uncommon reasons for FI is Anorectal Malformations (ARMs). An ARM is a congenital anomaly that affects somewhere between 1/2500 and 1/5000 live born babies. READ MORE

  4. 2. Reducing Attrition via Improved Strategies for Pre-clinical Drug Discovery : SPR-biosensor Aided Interaction Studies

    Author : Johan Winquist; Helena Danielson; Roderick E. Hubbard; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biokemi; Biochemistry;

    Abstract : The efficacy of a drug is tightly intertwined with its interaction mechanism with the drug target. The mechanism is dependent on the physicochemical and structural characteristics of both target and drug molecule.Drug discovery is plagued by a high attrition rate, whereas in the clinic, a major issue is drug resistance. READ MORE

  5. 3. Characterization of HCV Protease Inhibitors : Inhibition and Interaction Studies with Applications for Drug Discovery

    Author : Sofia Svahn Gustafsson; U. Helena Danielson; Johan Neyts; Uppsala universitet; []
    Keywords : Biokemi; Biochemistry;

    Abstract : In this thesis, different approaches based on inhibition and interactions studies, have been used to characterize inhibitors of the non-structural protein 3 (NS3) from the hepatitis C virus (HCV). This involves identification of enzyme inhibitory effects and characterization of interaction mechanisms and kinetics, as well as effects on replication in a cell based system and serum protein binding. READ MORE