Search for dissertations about: "Jonas W. Nilsson"

Found 1 swedish dissertation containing the words Jonas W. Nilsson.

2. 1. Cooperative Reactive Sites in Designed Helix-Loop-Helix Polypeptide Catalysts

   Author : Jonas W. Nilsson; Paolo Scrimin; Linköpings universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES;

   Abstract : Designed polypeptides, which fold into helix-loop-helix motifs and dimerise to four-helix bundles have been used as scaffolds for the introduction of catalytic activity for the hydrolysis of p-nitrophenyl esters. The reactive sites were based on the reactivity of histidine, and two His residues separated by four residues in the sequence was shown to be the minimal reactive site for the efficient hydrolysis of nitrophenyl esters. READ MORE