Search for dissertations about: "Jonathan Martin"

Showing result 1 - 5 of 11 swedish dissertations containing the words Jonathan Martin.

  2. 1. Ligand-based Methods for Data Management and Modelling

    Author : Jonathan Alvarsson; Jarl E. S. Wikberg; Ola Spjuth; Claes Andersson; Martin Eklund; John P. Overington; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; QSAR; ligand-based drug discovery; bioclipse; information system; cheminformatics; bioinformatics; Farmaceutisk farmakologi; Pharmaceutical Pharmacology; Bioinformatik; Bioinformatics;

    Abstract : Drug discovery is a complicated and expensive process in the billion dollar range. One way of making the drug development process more efficient is better information handling, modelling and visualisation. The majority of todays drugs are small molecules, which interact with drug targets to cause an effect. READ MORE

  4. 2. Binding Free Energy Calculations on Ligand-Receptor Complexes Applied to Malarial Protease Inhibitors

    Author : Martin Nervall; Johan Åqvist; Jonathan Essex; Uppsala universitet; []
    Keywords : Molecular biology; Plasmodium falciparum; plasmepsins; linear interaction energy; docking; HIV1 reverse trancriptase; Molekylärbiologi;

    Abstract : Malaria is a widespread disease caused by parasites of the genus Plasmodium. Each year 500 million clinical cases are reported resulting in over one million casualties. The most lethal species, P. falciparum, accounts for ~90% of the fatal cases and has developed resistance to chloroquine. READ MORE

  5. 3. Opportunity cost in healthcare priority setting

    Author : Jonathan Siverskog; Martin Henriksson; Lars-Åke Levin; Werner Brouwer; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : The resources available for the public provision of health care are not unlimited. Cost-effectiveness evidence on new healthcare interventions can help us prioritise in order to use scarce resources wisely, but to interpret cost-effectiveness evidence, it may appear as if we must make trade-offs between life and money. This is not so. READ MORE

  6. 4. Transition metal-catalysed isomerisation of allylic alcohols : Applications to C−C, C−F and C−Cl bond formation

    Author : Nanna Ahlsten; Belén Martín-Matute; M. J. Jonathan Williams; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; transiton metal-catalysis; allylic alcohols; isomerisation; halogenation; organisk kemi; Organic Chemistry;

    Abstract : The focus of this thesis has been to develop selective and atom-economical methods for carbon-carbon and carbon-heteroatom bond formation, and to some extent improve on existing findings in this area. More specifically, methods for the catalytic generation of enolates from allylic alcohols and their in situ functionalisation with electrophilic reagents are described. READ MORE

  7. 5. Contribution of polyfluoroalkyl phosphate esters (PAPs) and other precursor compounds to perfluoroalkyl carboxylates (PFCAs) in humans and the environment

    Author : Ulrika Eriksson; Anna Kärrman; Bert van Bavel; Gunilla Lindström; Jonathan Martin; Örebro universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; PAPs; precursors; PFCA; exposure; indoor dust; human serum; WWTP; bird eggs; Chemistry; Kemi;

    Abstract : Per-and polyfluoroalkyl substances (PFAS) are anthropogenic compounds that have been spread all over the world. The use of fluorotelomer compounds, short-chained homologues, and other PFASs with perfluorinated moieties has emerged recent years. READ MORE