Search for dissertations about: "Joy Zuchero"

Found 2 swedish dissertations containing the words Joy Zuchero.

  2. 1. Harnessing the molecular Trojan horse : Evaluating properties of preclinical Aβ immunoPET radioligands for optimized brain delivery via the transferrin receptor

    Author : Gillian Bonvicini; Stina Syvänen; Johanna Fälting; Dag Sehlin; Ken Honek; Sahar Roshanbin; Joy Zuchero; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Transferrin receptor TfR ; bispecific antibody; brain delivery; positron emission tomography PET ; Alzheimer’s disease; pharmacokinetics; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik; Biomedical Radiation Science; Biomedicinsk strålningsvetenskap;

    Abstract : With high specificity and selectivity to targets, antibodies are prime candidates for positron emission tomography (PET) radioligands. They do not passively cross the blood-brain barrier which has hindered their development for imaging intrabrain targets, like amyloid-β (Aβ) in Alzheimer’s disease. READ MORE

  4. 2. Enhancing the therapeutic effect of biological drugs with protein engineering : Focusing on pre-clinical Alzheimer’s disease therapy

    Author : Fadi Rofo; Greta Hultqvist; Stina Syvänen; Sara Mangsbo; Joy Zuchero; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer’s disease; amyloid-beta; blood-brain barrier; transferrin receptor; protein-drugs; multivalent-bispecific antibodies;

    Abstract : Aggregation of the amyloid-β peptide (Aβ) is one of the main pathological hallmarks in Alzheimer’s disease (AD). The soluble Aβ aggregates (oligomers and protofibrils) have shown to be the most harmful species. Hence, targeting these aggregates can be of therapeutic potential. READ MORE