Search for dissertations about: "Jyoti Chattopadhyaya"

Showing result 1 - 5 of 7 swedish dissertations containing the words Jyoti Chattopadhyaya.

  2. 1. Studies on the Non-covalent Interactions (Stereoelectronics, Stacking and Hydrogen Bonding) in the Self-assembly of DNA and RNA

    Author : Parag Acharya; Jyoti Chattopadhyaya; Frank Seela; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Bioorganic chemistry; nucleic acids; NMR; Stereoelectronic effects; Hydrogen Bonding; Stacking; Bioorganisk kemi; Bioorganic chemistry; Bioorganisk kemi;

    Abstract : This thesis is based on ten publications (Papers I-X). The phosphodiester backbone makes DNA or RNA to behave as polyelectrolyte, the pentose sugar gives the flexibility, and the aglycones promote the self-assembly or the ligand-binding process. READ MORE

  4. 2. Some Aspects of Physicochemical Properties of DNA and RNA

    Author : Sandipta Acharya; Jyoti Chattopadhyaya; Piet Herdewijn; Uppsala universitet; []
    Keywords : Bioorganic chemistry; nucleic acids; hydrogen-bonding; stacking; single-stranded; NMR; molecular dynamics; Bioorganisk kemi;

    Abstract : This thesis is based on nine research publications (I – IX) on structure and reactivity of RNA vis-à-vis DNA. The DNA and RNA are made of flexible pentose sugar units, polyelectrolytic phosphodiester backbone, and heterocyclic nucleobases. DNA stores our genetic code, whereas RNA is involved both in protein biosynthesis and catalysis. READ MORE

  5. 3. Conformationally Constrained Nucleic Acids as Potential RNA Targeting Therapeutics

    Author : Zhou Chuanzheng; Jyoti Chattopadhyaya; Serge Beaucage; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Bioorganic chemistry; Bioorganisk kemi; Chemistry with specialization in Bioorganic Chemistry; Kemi med inriktning mot bioorganisk kemi;

    Abstract : .... READ MORE

  6. 4. Conformationally Constrained Nucleosides, Nucleotides and Oligonucleotides : Design, Synthesis and Properties

    Author : Dmytro Honcharenko; Jyoti Chattopadhyaya; Piet Herdewijn; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Bioorganic chemistry; antisense oligonucleotides; conformationally constrained nucleosides; azetidine; aza-ENA; target affinity; RNase H; exonuclease stability; pyrene-functionalized nucleotides; fluorescence; mismatch discrimination; Bioorganisk kemi; Cell and molecular biology; Cell- och molekylärbiologi;

    Abstract : This thesis is based on six original research publications describing synthesis, structure and physicochemical and biochemical analysis of chemically modified oligonucleotides (ONs) in terms of their potential diagnostic and therapeutic applications. Synthesis of two types of bicyclic conformationally constrained nucleosides, North-East locked 1',2'-azetidine and North locked 2',4'-aza-ENA, is described. READ MORE

  7. 5. Studies on Nucleic Acids – Structure and Dynamics

    Author : Johan Isaksson; Jyoti Chattopadhyaya; Douglas H. Turner; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Bioorganic chemistry; nucleic acids; modified nucleotides; NMR; structure; dangling-end; single-stranded; thermodynamics; hydration; Bioorganisk kemi; Bioorganic chemistry; Bioorganisk kemi;

    Abstract : This thesis is based on six papers, Papers I-VI, focusing on the interplay between the stabilizing elements of nucleic acids self-assembly; hydrogen bonding, stacking and solvent effects. In Paper I we investigate how the substitution of the O4' for CH2 in the sugar moiety of adenosine (2'-deoxyaristeromycin) at the A6 position of the Dickerson-Drew dodecamer makes the two modified bases exist in a dynamic equilibrium between Hoogsteen and Watson-Crick base pairing in the NMR time scale. READ MORE