Search for dissertations about: "K. lactis"
Showing result 1 - 5 of 6 swedish dissertations containing the words K. lactis.
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1. Mating type switching and transcriptional silencing in Kluyveromyces lactis
Abstract : To explore the similarities and differences of regulatory circuits among budding yeasts, we characterized the role of unscheduled meiotic gene expression 6 (UME6) and a novel mating type switching pathway in Kluyveromyces lactis. We found that Ume6 was required for transcriptional silencing of the cryptic mating-type loci HMLα and HMRa. READ MORE
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2. The Kluyveromyces lactis killer toxin is a transfer RNA endonuclease
Abstract : Killer strains of the yeast Kluyveromyces lactis secrete a heterotrimeric protein toxin (zymocin) to inhibit the growth of sensitive yeasts. The cytotoxicity of zymocin resides in the γ subunit (γ-toxin), however the mechanism of cytotoxicity caused by γ-toxin was previously unknown. READ MORE
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3. Regulation and mechanism of mating-type switching in Kluyveromyces lactis
Abstract : Transposable elements (TEs) have had immense impact on the structure, function and evolution of eukaryotic genomes. The work in this thesis identified Kat1, a novel domesticated DNA transposase of the hAT family in the yeast Kluyveromyces lactis. Kat1 triggers a genome rearrangement that results in a switch of mating type from MATa to MATα. READ MORE
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4. Characterization of Budding Yeast Nonhomologous End-Joining at DNA Double-Strand Breaks and Telomeres
Abstract : The yeast K. lactis efficiently integrates DNA by illegitimate recombination (IR). IR was completely dependent upon nonhomologous end-joining (NHEJ). In contrast to S. READ MORE
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5. Silencing and DNA double-strand break repair in budding yeast
Abstract : Transcriptional silencing that makes large chromosomal domains inaccessible for the transcriptional apparatus is nucleated at DNA elements called silencers. In K.lactis a 102bp HMLα silencer was defined revealing three distinct protein-binding regions (A, B, and C) that were required for silencing of HMLα. READ MORE