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Showing result 1 - 5 of 37 swedish dissertations matching the above criteria.

  2. 1. PCR detection of Streptococcus pneumoniae and Haemophilus influenzae in pneumonia patients

    Author : Guma M. K. Abdeldaim; Björn Herrmann; Jonas Blomberg; Kristoffer Strålin; Birgitta Henriques; Uppsala universitet; []
    Keywords : Lower respiratory tract infections; Pneumonia; Streptococcus pneumoniae; Haemophilus influenzae; real-time PCR;

    Abstract : PCR is a rapid, reproducible method for nucleic acid detection. However, this technology displays significant deficiencies when applied in clinical microbiology. This work’s aim was to improve current diagnostics and provide sensitive and quantitative real-time PCRs. READ MORE

  4. 2. Evolutionary trajectories of Klebsiella pneumoniae : From experimental biofilm evolution to a hospital outbreak

    Author : Greta Zaborskytė; Linus Sandegren; Vaughn S. Cooper; Uppsala universitet; []
    Keywords : Klebsiella pneumoniae; evolution; experimental evolution; biofilms; infection; bacterial pathogens; Mikrobiologi; Microbiology;

    Abstract : Bacterial evolution is closely intertwined with our lives. As their hosts, we shape how bacteria evolve by imposing numerous selective pressures during the time bacteria spend in our bodies. As a result, they adapt in various ways to colonize us or infect us better. READ MORE

  5. 3. Multidrug-Resistant Escherichia coli and Klebsiella pneumoniae : Treatment, Selection and International Spread

    Author : Thomas Tängdén; Otto Cars; Anders Johansson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Escherichia coli; Klebsiella pneumoniae; extended-spectrum beta-lactamases; carbapenemases; metallo-beta-lactamases; synergy; antibiotic interventions;

    Abstract : The prevalence of Escherichia coli and Klebsiella pneumoniae producing extended-spectrum beta-lactamases (ESBLs) and carbapenemases is increasing worldwide. Therapeutic options for infections with these bacteria are limited not only by the production of ESBLs and carbapenemases, which confer resistance to cephalosporins and carbapenems, but also by frequent co-resistance to other antibiotics. READ MORE

  6. 4. Antibiotic resistance gone wild : A One Health perspective on carriage, selection and transmission of Extended-Spectrum Cephalosporinase- and Carbapenemase-producing Enterobacteriaceae

    Author : Clara Atterby; Josef D. Järhult; Nicola Williams; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Antibiotic resistance; E. coli; K. pneumoniae; ESBL; AmpC; Carbapenemase; ciprofloxacin resistance; colistin resistance; rural; wildlife; birds; sub-MIC; MSC; Cambodia; environment; epidemiology; Infektionssjukdomar; Infectious Diseases;

    Abstract : Antibiotics have saved millions of lives since they came into clinical use during the Second World War in the 1940s. Today, our effective use of antibiotics is under great threat due to emerging antibiotic resistance in bacteria. This thesis addresses the problems of antibiotic resistance from a ”One Health” perspective. READ MORE

  7. 5. Bacterial viruses targeting multi-resistant Klebsiella pneumoniae and Escherichia coli

    Author : Harald Eriksson; Anders Nilsson; Elisabeth Haggård-Ljungquist; Klas Flärdh; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Bacterial viruses; Bacteriophage; Phage; Phage therapy; multi-resistant bacteria; Klebsiella pneumoniae; molekylärgenetik; Molecular Genetics;

    Abstract : The global increase in antibiotic resistance levels in bacteria is a growing concern to our society and highlights the need for alternative strategies to combat bacterial infections. Bacterial viruses (phages) are the natural predators of bacteria and are as diverse as their hosts, but our understanding of them is limited. READ MORE