Search for dissertations about: "K562"

Showing result 1 - 5 of 30 swedish dissertations containing the word K562.

  2. 1. Functional studies of Wilms’ tumor gene 1 (WT1) in hematopoiesis and leukemia

    Author : Helena Svedberg; Avdelningen för hematologi och transfusionsmedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; extracellular fluids; Haematology; K562; U937; CD34 ; leukemia; WT1; hematopoiesis; Hematologi; extracellulära vätskor;

    Abstract : Wilms’ tumor gene 1 (WT1) is a zinc-finger transcription factor that is involved in the development of urogenital organs and mesothelial tissues. It was initially identified as a tumor suppressor gene, based on the observation that somatic inactivation of the gene predispose for development of the pediatric kidney cancer Wilms’ tumor. READ MORE

  4. 2. In vitro studies on anti-leukemic effects of tetracycline's analogues and cyclophosphamide

    Author : Mona Fares; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Leukemia is a heterogeneous group of hematological malignancies that originate from the bone marrow. Leukemias are classified as acute or chronic. Although acute leukemia affects patients of all ages, acute lymphoid leukemia is predominant in children and young adults while acute myeloid leukemia (AML) is predominant in the elderly. READ MORE

  5. 3. Leukemia chemotherapy : experimental studies on pharmacological optimisation

    Author : Michèle Masquelier; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Our main goal has been to identify new means to improve chemotherapy of acute leukaemia: 1. By using low-density lipoprotein (LDL) as a drug carrier to increase the selectivity of antileukemic drugs, based on high LDL uptake in acute myeloid leukemia (AML) cells. READ MORE

  6. 4. Topoisomerase II and drug resistance in leukemic cells

    Author : Rong Zhou; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Mechanisms for resistance to chemotherapy include among other, elevated p-glycoprotein (p-gp) level and/or altered topoisomerase II level (topo II). The present study focused on topo 11 expression, and the enzyme related in vitro drug sensitivities in human myeloid leukemic K562 cell line and isolated peripheral mononuclear cells from patients with acute myelogenous leukemia (AML), and with chronic lymphocytic leukemia (CLL). READ MORE

  7. 5. Study of the psoriasis proteome and analysis of MHC class I expression and function

    Author : Lina Carlén; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Complex disease; psoriasis; proteomics; human leukocyte antigen C HLA-C ; major histocompatibility complex; 2D PAGE; inflammation; skin disease;

    Abstract : Psoriasis is a common inflammatory skin disease affecting approximately 2% of the population in Sweden. Psoriasis displays clinical heterogeneity leading to several different types of manifestations, among them chronic plaque and acute guttate psoriasis. READ MORE