Search for dissertations about: "KIR"

Showing result 1 - 5 of 27 swedish dissertations containing the word KIR.

  2. 1. Immunotherapy and immunosuppression in myeloid leukemia

    Author : Alexander Hallner; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Natural killer cells; acute myeloid leukemia; histamine dihydrochloride; immunotherapy; reactive oxygen species; chronic myelomonocytic leukemia; NK cell education; NKG2A; HLA; KIR;

    Abstract : Acute myeloid leukemia (AML) and chronic myelomonocytic leukemia (CMML) are potentially life-threatening blood cancers characterized by the expansion of malignant myeloid cells in bone marrow and other organs. This thesis aimed at contributing to the understanding of the role of natural killer (NK) cells in AML and CMML with focus on the potential impact of the immunosuppression exerted by reactive oxygen species (ROS) formed by the myeloid cell NOX2 enzyme. READ MORE

  4. 2. On cellular immunology in chronic idiopathic thrombocytopenic purpura (ITP)

    Author : Per-Ola Andersson; Göteborgs universitet; []
    Keywords : chronic ITP; T-cells; TGF-b1; Th3; cell-mediated cytotoxicity; KIR; DNA microarray;

    Abstract : Chronic idiopathic thrombocytopenic purpura (ITP) is an acquired autoimmune disease characterized by a low platelet count and mucocutaneous bleedings. Chronic ITP is considered to be mediated by autoantibodies leading to premature destruction of platelets in the reticuloendothelial system. READ MORE

  5. 3. HLA and KIR gene polymorphism in hematopoietic stem cell transplantation

    Author : Marie Schaffer; Karolinska Institutet; Karolinska Institutet; []
    Keywords : HLA; KIR; NK cells; hematopoietic stem cell transplantation; unrelated donor;

    Abstract : The major histocompatibility complex (MHC) in humans known as the Human Leukocyte Antigens (HLA) is localised to the short arm of chromosome six. The HLA class 1 antigens, HLA-A, -B and -C are highly polymorphic glycoproteins expressed on the cell surface of most nucleated cells in the body. READ MORE

  6. 4. Formation of the inhibitory KIR repertoire in human natural killer cells

    Author : Sandra Andersson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Natural killer (NK) cells are lymphocytes of the innate immune system that are able to secrete cytokines and detect virus infected and transformed cells. Contrary to T cells, NK cells recognize targets that lack expression of MHC class I molecules at the cell surface, a phenomenon referred to as “missing self” recognition. READ MORE

  7. 5. Immunogenetic markers in immune mediated diseases

    Author : Liene Nikitina-Zake; Karolinska Institutet; Karolinska Institutet; []
    Keywords : HLA; MICA; TNFA; TNFa; KIR; CIN; cervical cancer; juvenile arthritis; MCTD; type I diabetes mellitus;

    Abstract : The aim of this thesis was to study HLA class II markers, as well as other - MHC and non MHC genes in different immune - mediated diseases, namely, cervical intraepithelial neoplasia (CIN), cervical cancer, juvenile idiopathic arthritis (JIA), mixed connective tissue disease (MCTD) and type I diabetes mellitus (T1 DM). HLA class II genes are located on the short arm of chromosome 6 and are known to be important for pathogenesis of immune-mediated diseases due to the function of the molecules these genes encode. READ MORE