Search for dissertations about: "KIRs"

Showing result 1 - 5 of 11 swedish dissertations containing the word KIRs.

  1. 1. Immunological responses in genital HPV infections and etiology of cervical cancer

    Author : Lisen Arnheim; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; HPV; CIN; cervical cancer; antibodies; KIRs; CXCL8; IFN-gamma; Chlamydia trachomatis;

    Abstract : Cervical cancer is one of the most common forms of cancers in women. Every year approximately 450,000 women are diagnosed worldwide and 200,000 die. The sexually transmitted oncogenic human papillomavirus (HPV) types are established as the major etiological agents of cancer of the cervix. READ MORE

  2. 2. A study on the role of genes of innate immunity in type 1 diabetes

    Author : Saikiran K Sedimbi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : Type 1 diabetes (T1D) is caused by autoimmune destruction of insulin-producing pancreatic beta-cells. It is a polygenic disease in which maximal genetic susceptibility is conferred by the presence of MHC class II genes. READ MORE

  3. 3. A study of biomarker analysis in association with type 1 diabetes and their shared features in rheumatoid arthritis

    Author : Chengjun Sun; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : Type 1 diabetes (T1D) is mediated by abnormal immune system (autoimmunity) that targeting specifically to self insulin-producing cells (β-cells). People with T1D require treatments based on life-long insulin substitution. READ MORE

  4. 4. The ontogeny and regulation of human natural killer cells

    Author : Martin A. Ivarsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : Natural Killer (NK) cells are members of the innate lymphoid cell (ILC) family and take part in the detection and eradication of virus-infected and transformed cells. In this thesis, together with my colleagues I have investigated how NK cells and other ILCs develop and function during human fetal development, how NK cells are functionally regulated (educated) via the activating receptor KIR2DS1, and how NK cells in our body are affected during the early phase of an acute viral infection. READ MORE

  5. 5. Immune repertoire diversity in allogeneic stem cell transplantation and its implications for infections and the graft versus leukemia effect

    Author : Andreas Björklund; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : The beneficial graft versus leukemia effect (GVL) and its detrimental counterparts, graft versus host disease (GVHD) and susceptibility to infections, are all coupled to a multitude of events during the immune reconstitution (IR) after hematopoietic stem cell transplantation (HSCT). The general aim of this thesis has been to learn more about the IR in HSCT with a particular focus on the impact of infections, natural killer (NK) cell mediated GVL effects and the possibility to apply GVL effects in adoptive cell therapy. READ MORE