Search for dissertations about: "Kardiovaskulära systemet"
Showing result 6 - 10 of 88 swedish dissertations containing the words Kardiovaskulära systemet.
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6. Expression and Regulation of P2 Receptors in Human Circulation
Abstract : P2 receptors mediate the actions of the extracellular nucleotides ATP, ADP, UTP and UDP regulating several physiological responses including cardiac function, vascular tone, smooth muscle cell (SMC) proliferation, platelet aggregation, and the release of endothelial factors. The aim of the present study was to investigate the mRNA and protein expression of P2 receptors in human SMCs, endothelial cells (ECs), erythrocytes and platelets, the regulation of P2 receptors under shear stress in human vessels, the changes of platelet P2 receptors in patients with systemic lupus erythematosus (SLE) and the regulation of plasma ATP levels by P2 receptor on erythrocytes. READ MORE
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7. On cardiovascular responses to hypovolemic circulatory stress. An experimental study in man
Abstract : Aged subjects have a decreased tolerance to hypovolemia, which could contribute to their increased cardiovascular morbidity. One possible etiological factor might be an age-related reduction in the efficiency of the baroreceptor reflex axis. READ MORE
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8. Novel functions of cardiovascular P2 receptors
Abstract : The aim of the thesis was to examine the expression and function of the extracellular nucleotide P2 receptors in the cardiovascular system. In the cardiovascular system nucleotides are released during shear stress, hypoxia, ischemia, from endothelial cells, smooth muscle cells, aggregating platelets, inflammatory cells and erythrocytes. READ MORE
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9. Endothelium-derived Vasoactive Factors and Leukocyte-derived Inflammatory Mediators. Studies in subjects with or at risk for vascular disease
Abstract : This study was undertaken to evaluate relationships between endothelial function (assessed as mediators of endothelium-derived vasoactive factors such as nitric oxide [NO], prostacyclin [PGI2] and endothelin [ET-1] ), and risk factors for atherosclerosis, as well as to study possible relationships between endothelial function and leukocyte activation (indicated by measurements of leukocyte-derived inflammatory mediators) in subjects with or at risk for atherosclerosis. In subjects with asymptomatic atherosclerosis we found inverse relationships between cyclic guanosine monophosphate (cGMP) in platelets (mediator of NO activity) and both serum total cholesterol and plasma ET-1 suggesting that NO-mediated vasodilation may be impaired in hypercholesterolemia and that maintenance of vascular tone is achieved by a balance between NO and ET-1. READ MORE
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10. Tumor Necrosis Factor-alpha as a target cytokine in vascular disease
Abstract : Inflammation plays an important role in atherosclerosis. One of the most potent pro-inflammatory cytokines is tumor necrosis factor-alpha (TNF-a), a cytokine identified to have a pathogenic role in chronic inflammatory diseases such as rheumatoid arthritis (RA). READ MORE