Search for dissertations about: "Karin Herrlin"

Found 1 swedish dissertation containing the words Karin Herrlin.

2. 1. CYP2C19 catalyzed drug metabolism in different populations

   Author : Karin Herrlin; Karolinska Institutet; Karolinska Institutet; []
   Keywords : CYP2C19; drug metabolism; cytochrome P450; mephenytoin; omeprazole; proguanil chloroguanide ; citalopram; debrisoquine; CYP2D6; gene duplication; pharmacogenetics;

   Abstract : Metabolism catalyzed by the cytochrome P450 enzyme CYP2C19 varies between individuals, who can be either efficient (EM) or poor metabolizers (PM). In this thesis the metabolism of four different CYP2C19 substrates (citalopram, mephenytoin, omeprazole, and proguanil) was investigated in vivo in Africans (Ethiopians an Tanzanians) an in Swedish is Caucasians. READ MORE