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Showing result 1 - 5 of 108 swedish dissertations matching the above criteria.

  2. 1. Novel treatments of glioblastoma in experimental models

    Author : Karolina Förnvik; Neurokirurgi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Experimental glioma models; Glioblastoma; Complement system; C1 esterase inhibitor; ITPP; CRP; Glioma cells;

    Abstract : One of the major problems with malignant brain tumours, such as glioblastoma multiforme, is that despite being able to remove the major bulk of the tumour through surgery and treating the patients with chemotherapy and radiotherapy, we know that tumour cells have already spread throughout the brain. Furthermore, we now know that the glioblastoma cells effectively suppress the patients’ own anti-tumour response. READ MORE

  4. 2. Cerebellar function during development. Eyeblink conditioning, prism adaptation and interval production in children and adults

    Author : Karolina Löwgren; foniatri och audiologi Logopedi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cerebellum; Eyeblink conditioning; Prism adaptation; Finger tapping; Development; Children; Adults; Cerebellar function; Neurodevelopmental disorders; Cognitive disorders;

    Abstract : The focus of this thesis is on cerebellar-dependent sensorimotor tasks during development. The performance in classical delay eyeblink conditioning, prism adaptation, and isochronous serial interval production (finger tapping) was explored in typically developing school-aged children, young adolescents, and adults. READ MORE

  5. 3. Modeling and Optimization of Reversed-Phase Chromatography : Effects of Modulators and Temperature

    Author : Karolina Arkell; Avdelningen för kemiteknik; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Reversed-phase chromatography; Hydrophobic interaction chromatography; Mechanistic modeling; INSULIN; KCl; Ethanol; Temperature; Multi-objective optimization; Constraint; Solubility;

    Abstract : Many widespread diseases, such as diabetes, various types of cancer, and aggressive versions of influenza, are treated or prevented with biopharmaceuticals. Biopharmaceuticals are drugs that are based on proteins, peptides, antibodies, attenuated viruses (vaccines), and other biomolecules that are synthesized predominately in bacteria, yeast, and mammalian cells. READ MORE

  6. 4. Origin and the evolution of diatoms through the integration of paleontology and phylogenetics

    Author : Karolina Brylka; Berggrundsgeologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; diatoms; evolution; fossil record; Cretaceous; molecular evolution; Mesozoic; silicon transporter proteins; gene duplication;

    Abstract : Diatoms, the prominent photosynthetic eucaryotes, have inhabited the world’s oceans for at least the past 120 Ma since their first appearance in the Lower Cretaceous. There are also records of older diatoms, from the Jurassic dating to ca. 172 Ma and ca. 165 Ma, however these are poorly documented. READ MORE

  7. 5. TNFalpha expression in monocytes/macrophages

    Author : Karolina Andersson; Institutionen för experimentell medicinsk vetenskap; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomedicinska vetenskaper allmänt ; General biomedical sciences; Protein kinase; Macrophage; TNF;

    Abstract : The recognition of microbes or microbial products by leukocytes is a key event in innate immunity. Binding of microbial products to cell surface receptors on phagocytes induce a response that includes the production of inflammatory mediators. One such mediator is the cytokine tumour necrosis factor alpha (TNF). READ MORE