Search for dissertations about: "Kemi med inriktning mot bioorganisk kemi"

Found 3 swedish dissertations containing the words Kemi med inriktning mot bioorganisk kemi.

  1. 1. Conformationally Constrained Nucleic Acids as Potential RNA Targeting Therapeutics

    Author : Zhou Chuanzheng; Uppsala universitet.; Uppsala universitet.; [2010]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURAL SCIENCES Chemistry Organic chemistry Bioorganic chemistry; NATURVETENSKAP Kemi Organisk kemi Bioorganisk kemi; Chemistry with specialization in Bioorganic Chemistry; Kemi med inriktning mot bioorganisk kemi;

    Abstract : .... READ MORE

  2. 2. Peptide Conjugates as Useful Molecular Tools

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Adam T. Ślósarczyk; Uppsala universitet.; [2011]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; peptide conjugates; designed peptides; polypeptides; molecular recognition; linker; linking technology; bioconjugation; conjugation; conjugates; Kemi; Chemistry; Chemistry with specialization in Bioorganic Chemistry; Kemi med inriktning mot bioorganisk kemi;

    Abstract : The conjugation of a small organic molecule to synthetic polypeptides from a designed set has been shown to give rise to binders with high affinity and selectivity for the phosphorylated model proteins α-casein and β-casein but not for ovoalbumin. The small organic molecule that was used for this purpose is comprised of two di-(2-picolyl)amine groups assembled on a dimethylphenyl scaffold, and is capable of complexing two Zn2+ ions to form chelates that bind the phosphate ion. READ MORE

  3. 3. Conformationally Constrained Oligonucleotides for RNA Targeting

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Qing Li; Uppsala universitet.; [2012]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; conformationally constrained nucleoside; antisense oligonucleotide; RNA affinity; nuclease stability; RNase H; RNA degradation; Chemistry with specialization in Bioorganic Chemistry; Kemi med inriktning mot bioorganisk kemi;

    Abstract : A short oligonucleotide sequence as in a single-stranded antisense oligo nucleotides (AON) or in double-stranded small interfering RNAs (siRNA) can modulate the gene expression by targeting against the cellular mRNA, which can be potentially exploited for therapeutic purposes in the treatment of different diseases. In order to improve the efficacy of oligonucleotide-based drugs, the problem of target affinity, nuclease stability and delivery needs to be addressed. READ MORE