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Showing result 1 - 5 of 15 swedish dissertations matching the above criteria.

  2. 1. Release of coexisting neurotransmitters : in vitro studies on the release of the putative neurotransmitters serotonin, substance P and TRH from rat ventral spinal cord

    Author : Kerstin Iverfeldt; Stockholms universitet; []
    Keywords : ;

    Abstract : .... READ MORE

  4. 2. Processing of the amyloid precursor protein and its paralogues amyloid precursor-like proteins 1 and 2

    Author : Linda Adlerz; Kerstin Iverfeldt; Richard Cowburn; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; APP; APLP1; APLP2; Alzheimer s disease; Amyloid β-peptide; Processing; RA; BDNF; IGF-1; curcumin; PI3-K; MAPK; cdk5; Neurochemistry; Neurokemi; Neurochemistry and Molecular Neurobiology; neurokemi med molekylär neurobiologi;

    Abstract : Alzheimer’s disease (AD) is a neurodegenerative disorder which is histopathologically characterised by amyloid plaques and neurofibrillary tangles. Amyloid plaques consist of the amyloid β-peptide (Aβ) that can form aggregates in the brain. Aβ is generated from the amyloid precursor protein (APP) through proteolytic cleavage. READ MORE

  5. 3. Temporal events in neuronal differentiation and cell death : expression and processing of the Alzheimer's amyloid precursor protein family and a protein at the nuclear pore

    Author : Marie Beckman; Kerstin Iverfeldt; David H. Small; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurochemistry; Neurokemi; Neurochemistry and Neurotoxicology; neurokemi och neurotoxikologi;

    Abstract : The present study had two major objectives: 1) to elucidate the involvement of Alzheimer’s amyloid precursor protein (APP) family in neuronal differentiation, and the effect of the Alzheimer’s disease (AD)-linked mutation APPV642I on signal transduction; 2) to investigate the fate of the nuclear pore complex protein POM121 during apoptosis and to examine the possibility of using green fluorescent protein (GFP)-labelled POM121 as a non-invasive sensor of apoptosis in living (non-fixed) cells.APP is the parent protein of the b-amyloid peptide, which is the major peptide constituent in the “senile plaques” of AD. READ MORE

  6. 4. Inflammatory cytokines and NFκB in Alzheimer’s disease

    Author : Linda Fisher; Kerstin Iverfeldt; Illana Gozes; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; β-amyloid; interleukin-1; interleukin-6; cell-penetrating peptide; PNA; Neurochemistry; Neurokemi;

    Abstract : Alzheimer’s disease is the most common form of dementia. It is a neurodegenerative disorder characterized by extracellular senile plaques and intracellular neurofibrillary tangles. The main constituent of the senile plaques is the neurotoxic β-amyloid peptide. READ MORE

  7. 5. Neuroblastoma cells: in vitro studies on childhood cancer and amyloid precursor protein processing enzymes

    Author : Tom Gatsinzi; Kerstin Iverfeldt; Erik Walum; Stockholms universitet; []
    Keywords : neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Abstract : .... READ MORE