Search for dissertations about: "Kerstin Iverfeldt"

Showing result 6 - 10 of 15 swedish dissertations containing the words Kerstin Iverfeldt.

  2. 6. Regulation of apoptotic processes in neurodegeneration and cancer : In vitro studies on human neuroblastoma cells

    Author : Tom Gatsinzi; Kerstin Iverfeldt; Thomas J. Sayers; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Abstract : Apoptosis is a highly controlled process of cell death, which is vital for maintenance of all multicellular organisms. Aberrant regulation of apoptosis can give rise to pathological conditions such as neurodegenerative diseases and cancer. READ MORE

  4. 7. Proteolytic processing of the Alzheimer APP protein family during neuronal differentiation

    Author : Sofia Holback; Kerstin Iverfeldt; Nigel Hooper; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; APP; APLP1; APLP2; differentiation; processing; retinoic acid; secretase; Neurochemistry; Neurokemi; Neurochemistry and Molecular Neurobiology; neurokemi med molekylär neurobiologi;

    Abstract : Increased amyloid-β (Aβ) load in the brain, neurite degeneration, neuronal loss, and decreased levels of several neurotrophins are among the characteristics of Alzheimer’s disease (AD). Generation of Aβ occurs when the amyloid precursor protein (APP) is proteolytically processed by β- and γ-secretases in the amyloidogenic pathway. READ MORE

  5. 8. Caspase activation in human neuroblastoma cells: mechanisms and spatiotemporal aspects

    Author : Elena V. Ivanova; Kerstin Iverfeldt; Boris Zhivotovsky; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; apoptosis; caspase; local caspase activation; neurodegeneration; tau-anchored FRET sensors; tAFS; cancer; neuroblastoma; TNF-related apoptosis inducing ligand; TRAIL; protein kinase C; PKC; X-linked inhibitor of apoptosis protein; XIAP; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Abstract : Apoptosis is one of the modes of programmed cell death, in which several members of the caspase family of proteases play the central role. However, activation of apoptotic caspases does not necessarily lead to cell death. READ MORE

  6. 9. Processing of the APP family by the α-secretases ADAM10 and TACE

    Author : Kristin Jacobsen; Kerstin Iverfeldt; Lars Nilsson; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurochemistry; Neurokemi; Neurochemistry and Molecular Neurobiology; neurokemi med molekylär neurobiologi;

    Abstract : Alzheimer’s disease (AD) is a progressive neurodegenerative disease, which is characterized by formation of amyloid plaques in the brain. The major constituent of these plaques is the hydrophobic peptide Aβ. Aβ accumulation is considered to be the main cause of the pathology seen in AD brains. READ MORE

  7. 10. α-Secretase processing of the Alzheimer amyloid-β precursor protein and its homolog APLP2

    Author : Kristin Jacobsen; Kerstin Iverfeldt; Olav Andersen; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; APP; APLP2; ADAM10; TACE; Alzheimer s Disease; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Abstract : The amyloid-β precursor protein (APP) has been widely studied due to its role in Alzheimer´s disease (AD). When APP is sequentially cleaved by β- and γ-secretase, amyloid-β (Aβ) is formed. Aβ is prone to aggregate and is toxic to neurons. READ MORE