Search for dissertations about: "Ki67"

Showing result 6 - 10 of 63 swedish dissertations containing the word Ki67.

  2. 6. Improving biomarker assessment in breast pathology

    Author : Stephanie Robertson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The accuracy of prognostic and therapy-predictive biomarker assessment in breast tumours is crucial for management and therapy decision in patients with breast cancer. In this thesis, biomarkers used in clinical practice with emphasise on Ki67 and HER2 were studied using several methods including immunocytochemistry, in situ hybridisation, gene expression assays and digital image analysis, with the overall aim to improve routine biomarker evaluation and clarify the prognostic potential in early breast cancer. READ MORE

  4. 7. Validation of biomarkers and digital image analysis in breast pathology

    Author : Gustav Stålhammar; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : For women worldwide, the risk of developing breast cancer is second only to that of nonmelanoma skin cancer. Significant improvements have been made in survival over the past decades and today about 80 % of the patients survive 10 years or more after their breast cancer diagnosis. READ MORE

  5. 8. Prognostic factors in breast cancer with a focus on the role of tumour proliferation

    Author : Claudette Falato; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Ki67 is the most commonly used marker of proliferation in breast cancer. The general aim of the thesis was to investigate the prognostic role of Ki67 and its interplay with other prognostic factors in breast cancer cohorts. READ MORE

  6. 9. The Prognostic Impact of Proliferation Markers in Breast Cancer with Emphasis on Cyclin B1 and PPH3

    Author : Anthoula Koliadi; Marie-Louise Fjällskog; Thomas Hatschek; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; proliferation; cyclin B1; Phosphorylated Histone 3; cyclin A; breast cancer; node negative; prognostic factor; luminal; Oncology; Onkologi;

    Abstract : The aim of this thesis was to investigate the prognostic role of the proliferation markers cyclin B1 and Phosphorylated Histone 3 (PPH3) in breast cancer (BC).In paper I we used an experimental study design, we compared women dying early from their BC with women free from relapse more than eight years after initial diagnosis. READ MORE

  7. 10. Prognostic markers in breast cancer associated with cell cycle control, proliferation and angiogenesis

    Author : Thomas Lindahl; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Breast cancer; TP53; VEGF; cyclin E; Ki-67; MIB-1; p21; MDM-2; survival; prognostic markers;

    Abstract : This thesis focuses on potential prognostic molecular breast cancer markers which are related to angiogenesis, proliferation or cell cycle control. A common denominator for all of the investigated markers in the thesis is either hypothesized or previously reported association with the tumor suppressor gene TP53. READ MORE