Search for dissertations about: "Kidney mitochondria"

Showing result 1 - 5 of 17 swedish dissertations containing the words Kidney mitochondria.

  2. 1. The Role of Kidney Oxygen Homeostasis for the Development of Kidney Disease

    Author : Carla Carvalho; Fredrik Palm; Peter Hansell; Malou Friederich; Jenny Nyström; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oxygen; Kidney mitochondria; Hypoxia-inducible factors; Prolyl hydroxylase; von Hippel-Lindau; Diabetes; Aging; Kidney; Sodium; RAAS; Fysiologi; Physiology;

    Abstract : The relation between oxygen supply and demand determines tissue oxygen tension (PO2). When intrarenal tissue PO2 decreases, any compensatory increase in oxygen supply via increased renal blood flow is likely to increase glomerular filtration rate. READ MORE

  4. 2. The Role of Mitochondrial Uncoupling in the Development of Diabetic Nephropathy

    Author : Malou Friederich Persson; Fredrik Palm; Richard K. Porter; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Kidney; mitochondria; Uncoupling Protein-2; Adenosine Nucleotide Transporter; uncoupling; diabetes; diabetic nephropathy; db db; dinitrophenol; Coenzyme Q10; oxygen; rats; mice; Physiology; Fysiologi; Medical Cell Biology; Medicinsk cellbiologi;

    Abstract : Diabetes is closely associated with increased oxidative stress, especially originating from the mitochondria. A mechanism to reduce increased mitochondria superoxide production is to reduce the mitochondria membrane potential by releasing protons across the mitochondria membrane. READ MORE

  5. 3. Aspects of renal blood flow and oxygenation in acute kidney injury during severe infections

    Author : Tomas Luther; Robert Frithiof; Michael Hultström; Per Liss; Rafael Kawati; Anders Åneman; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Acute kidney injury; renal blood flow; renal oxygenation; COVID-19; fluids; mitochondria; sepsis; acute respiratory distress syndrome; magnetic resonance imaging; Anestesiologi och intensivvård; Anaesthesiology and Intensive Care;

    Abstract : Acute kidney injury (AKI) is a common complication in patients treated in the intensive care unit (ICU). Severe infections/sepsis is the most common aetiology, and about half of patients treated in the ICU due to sepsis are affected. Although AKI often resolves over time, the development of AKI decreases the chances of surviving. READ MORE

  6. 4. Oxygen Metabolism in Experimental Kidney Disease

    Author : Ebba Sivertsson; Fredrik Palm; Peter Hansell; Jenny Nyström; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Kidney; kidney oxygenation; mitochondria; proteinuria; uncoupling protein; adenosine nucleotide transporter; diabetes; hyperthyroidism; thyroid hormone; hypertension; angiotensin II; CDK; AST-120; rats; mice; Fysiologi; Physiology;

    Abstract : Tubulointerstitial hypoxia has been proposed a unifying mechanism behind the development of chronic kidney disease (CKD), regardless of primary diagnosis. Important factors that contribute to the development of hypoxia are reduced bioavailability of nitric oxide (NO), oxidative stress and mitochondria uncoupling. READ MORE

  7. 5. Mutant superoxide dismutase-1-caused pathogenesis in amyotrophic lateral sclerosis

    Author : Daniel Bergemalm; Stefan Marklund; Thomas Brännström; Peter Andersen; Caterina Bendotti; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ALS; SOD1; mitochondria; proteome; transgenic mice; inclusion; Clinical chemistry; Klinisk kemi; biokemi; Biochemistry; neurologi; Neurology; Clinical Chemistry; klinisk kemi; patologi; Pathology;

    Abstract : Amyotrophic lateral sclerosis (ALS) is a devastating disease that affects people in their late mid-life, with fatal outcome usually within a few years. The progressive degeneration of neurons responsible for muscle movement (motor neurons) throughout the central nervous system (CNS) leads to muscle wasting and paralysis, and eventually affects respiratory function. READ MORE