Search for dissertations about: "Kinins"

Showing result 1 - 5 of 6 swedish dissertations containing the word Kinins.

  1. 1. Kinins : important regulators in inflammation induced bone resorption

    Author : Anna Bernhold Brechter; Ulf Lerner; Hans-Erik Claesson; Umeå universitet; []
    Keywords : Bone resorption; Osteoblasts; Kinins; B1 and B2 receptors; IL-1β; TNF-α; Prostaglandin; COX-2; RANKL; Transcription factors; IL-4; IL-13; Medical Cell Biology; medicinsk cellbiologi;

    Abstract : Inflammatory processes in, or in close vicinity of, the skeleton often lead to loss of bone tissue. Different cytokines have been shown to be involved as stimulators of inflammatory induced osteoclastic bone resorption. READ MORE

  2. 2. Inflammation, kinins, and kinin receptors

    Author : Sara Bengtson; Infektionsmedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Evidence is accumulating that the pathogenesis of many diseases is triggered by inappropriate inflammatory responses. These serious complications may occur when the tightly regulated inflammatory network is out of balance and it is now clear that this can eventually cause substantial harm to own cells and tissues. READ MORE

  3. 3. Tissue kallikrein: pathophysiological role in acute pancreatitis

    Author : Mats Bläckberg; Helsingborg Kliniska Vetenskaper; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; acute pancreatitis; aprotinin; alpha-macroglobulin; alpha1-proteinase inhibitor; turn over; kinin B2 receptor; kallidin; bradykinin; Tissue kallikrein; kallistatin; Surgery; orthopaedics; traumatology; Kirurgi; ortopedi; traumatologi;

    Abstract : Tissue kallikrein releases pharmacollogically highly active kinins from kininogen. Many other enzymes may also release kinins. The aim of the study was to clarify the pathophysiological role of tissue kallikrein in acute pancreatitis. Two sensitive and specific radioimmunoassays for porcine and human tissue kallikrein were developed. READ MORE

  4. 4. Kinin System Activation in Vasculitis

    Author : Robin Kahn; Lund Pediatrik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; kinin receptors; inflammation; vasculitis; proteinase 3; neutophils; anti-neutrophil-cytoplasmic antibodies; Kinin;

    Abstract : The kinin system is activated when high-molecular-weight kininogen (HK) is cleaved by plasma kallikrein thus generating bradykinin. Bradykinin is a potent proinflammatory peptide that induces plasma leakage, blood pressure drop, liberation of inflammatory cytokines and pain. READ MORE

  5. 5. G protein-coupled receptor regulation: The role of protein interactions and receptor trafficking

    Author : Caroline Sandén; Drug Target Discovery; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; receptor trafficking; B1 receptor; receptor oligomerization; estrogen; GPER1; G protein-coupled estrogen receptor 1; EP24.15; BK; bradykinin; B1R; B2R; B2 receptor; GPCR; receptor maturation;

    Abstract : The superfamily of G protein-coupled receptors (GPCR) is the largest gene family in the human genome. GPCR-mediated signaling operates in every human cell, and about 50% of existing clinically useful drugs act through GPCR. READ MORE