Search for dissertations about: "Kioumars Delfani"

Found 1 swedish dissertation containing the words Kioumars Delfani.

2. 1. Neuronal dysfunction, death and repair in the MPTP model of Parkinson's disease

   Author : Kioumars Delfani; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Parkinson s Disease; apoptosis; substantia nigra; dopamine; MPTP; neurogenesis; intracranial transplantation; ATP; PET; stereology; diethyldithiocarbamate; 7-nitroindazole; mouse; squirrel monkey; non- human primate;

   Abstract : We have used mouse and non-human primate models of Parkinson's Disease to analyze neuronal dysfunction, death and repair in the mammalian brain, utilizing the neurotoxin 1-methyl-4-phenyl1,2,3,6-tetrahydropyridine (MPTP). In a series of experiments we assessed the effects of diethyIdithiocarbamate (DDC) on MPTP toxicity, analyzing striatal and midbrain dopamine levels as well as neuronal loss. READ MORE