Search for dissertations about: "Klinisk immunologi"

Showing result 21 - 25 of 329 swedish dissertations containing the words Klinisk immunologi.

  2. 21. CNS-Targeted Cell Therapy for Multiple Sclerosis

    Author : Moa Fransson; Angelica Loskog; Tomas Olsson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CAR; Targeting; Suppressive cells; Foxp3; Tregs; Clinical immunology; Klinisk immunologi; Immunologi; Immunology;

    Abstract : Multiple sclerosis (MS) is an autoimmune disorder of the central nervous system (CNS). In the current thesis, we have preformed an immunological investigation of patients with MS and developed an immunosuppressive cell therapy that could be beneficial for these patients. READ MORE

  4. 22. Immunological Checkpoint Blockade and TLR Stimulation for Improved Cancer Therapy

    Author : Sara Mangsbo; Thomas Tötterman; Angelica Loskog; Rolf Kiessling; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CpG ODNs; TLR-9; CTLA-4; PD-1; PD-L1; B7. H1; immunotherapy; checkpoint blockade; bladder cancer; cancer; complement; TLRs; Compstatin; properdin; C3; experimental animal model; whole blood loop system; combination therapies; Clinical immunology; Klinisk immunologi; Tumour immunology; Tumörimmunologi; immunologi; Immunology;

    Abstract : This thesis concerns the investigation of novel immunotherapies for cancer eradication. CpG therapy was used in order to target antigen-presenting cells (APCs), facilitating antigen presentation and activation of T cells. READ MORE

  5. 23. Myeloid-Derived Suppressor Cells and Other Immune Escape Mechanisms in Chronic Leukemia

    Author : Lisa Christiansson; Angelica S I Loskog; Ulla Olsson-Strömberg; Andreas Lundqvist; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; chronic myeloid leukemia; myeloid-derived suppressor cells; sCD25; tyrosine kinase inhibitors; multiplex protein quantification; Medical Science; Medicinsk vetenskap;

    Abstract : Chronic myeloid leukemia (CML) is characterized by the Philadelphia chromosome, a minute chromosome that leads to the creation of the fusion gene BCR/ABL and the transcription of the fusion protein BCR/ABL in transformed cells. The constitutively active tyrosine kinase BCR/ABL confers enhanced proliferation and survival on leukemic cells. READ MORE

  6. 24. Initiation of alternative pathway of complement, and development of novel liposomal coatings

    Author : Anna Adler; Yuji Teramura; Penti Tengvall; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; immunology; complement system; C3; liposomes; polymer-lipids; Immunologi; Immunology;

    Abstract : The complement system is a central part of the innate immune system, and is an essential part in recognizing and clearing non/altered-self surfaces in the body. This thesis comprises of projects in which the initiation of the alternative pathway (AP) of complement in the fluid phase as well on various artificial and lipid surfaces has been studied. READ MORE

  7. 25. Studies of Regulatory T cells with Implications for Clinical Applications

    Author : Marcus Bergström; Olle Korsgren; Wayne Hawthorn; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Regulatory T cell; Treg; Transplantation; Immunology; Tolerance; Islet transplantation; Immunosuppression; Immunologi; Immunology;

    Abstract : Regulatory T cells (Tregs) are vital for regulating immune homeostasis and for preventing immunopathology. The immunosuppressive functions of Tregs have raised hope for their potential use in clinical applications. READ MORE