Search for dissertations about: "Klinisk kemi"

Showing result 1 - 5 of 143 swedish dissertations containing the words Klinisk kemi.

  1. 1. Pilicides and Curlicides Design, synthesis, and evaluation of novel antibacterial agents targeting bacterial virulence

    University dissertation from Umeå : Umeå universitet, Kemiska Institutionen

    Author : Erik Chorell; Fredrik Almqvist; Stephen Hanessian; [2010]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pilicide; curlicide; anti-virulence; chaperone usher pathway; antibacterial; pili; curli; Escherichia coli; biofilm inhibitor; 2-pyridone; peptidomimetic; NATURAL SCIENCES Chemistry Organic chemistry; NATURVETENSKAP Kemi Organisk kemi; NATURAL SCIENCES Chemistry Organic chemistry Bioorganic chemistry; NATURVETENSKAP Kemi Organisk kemi Bioorganisk kemi; NATURAL SCIENCES Chemistry Organic chemistry Pharmaceutical chemistry; NATURVETENSKAP Kemi Organisk kemi Läkemedelskemi; NATURAL SCIENCES Chemistry Organic chemistry Organic synthesis; NATURVETENSKAP Kemi Organisk kemi Organisk syntes; MEDICINE Microbiology; immunology; infectious diseases Infectious diseases; MEDICIN Mikrobiologi; immunologi; infektionssjukdomar Infektionssjukdomar; Biorganic Chemistry; bioorganisk kemi; Infectious Diseases; infektionssjukdomar; datorlingvistik; computational linguistics; organisk kemi; Organic Chemistry;

    Abstract : New strategies are needed to counter the growing problem of bacterial resistance to antibiotics. One such strategy is to design compounds that target bacterial virulence, which could work separately or in concert with conventional bacteriostatic or bactericidal antibiotics. READ MORE

  2. 2. Biomarkers for Better Understanding of the Pathophysiology and Treatment of Chronic Pain Investigations of Human Biofluids

    University dissertation from Umeå : Umeå universitet, Kemiska Institutionen

    Author : Anne-Li Lind; Torsten Gordh; Masood Kamali-Moghaddam; Jonas Bergquist; Eva Kosek; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; chronic pain; neuropathic pain; lumbar radicular pain; amyotrophic lateral sclerosis; radiculopathy; fibromyalgia; pathophysiology; spinal cord stimulation; mechanism of action; disc herniation; cerebrospinal fluid; plasma; biomarker; human; protein; chemokines; cytokines; inflammation; neuroinflammation; mass spectrometry; proximity ligation assay; proximity extension assay; antibody suspension bead array; protein profiling; molecular medicine; personalized medicine; Anestesiologi och intensivvård; Anaesthesiology and Intensive Care; Biomedical Laboratory Science; Biomedicinsk laboratorievetenskap; Kemi med inriktning mot analytisk kemi; Chemistry with specialization in Analytical Chemistry; Medicinsk vetenskap; Medical Science; Molekylär medicin; Molecular Medicine;

    Abstract : Chronic pain affects 20 % of the global population, causes suffering, is difficult to treat, and constitutes a large economic burden for society. So far, the characterization of molecular mechanisms of chronic pain-like behaviors in animal models has not translated into effective treatments. READ MORE

  3. 3. Controlled release gel formulations and preclinical screening of drug candidates

    University dissertation from Umeå : Department of Chemistry

    Author : Tofeeq Ur-Rehman; Gerhard Gröbner; Mikael Elofsson; Åsa Gylfe; Martin Malmsten; [2011]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; poloxamer; drug delivery; micellization; DMSO; calorimetry; NMR. in situ gelation; chitosan; preclinical pharmacokinetics; type III secretion inhibitors; NATURAL SCIENCES Chemistry Physical chemistry; NATURVETENSKAP Kemi Fysikalisk kemi; Pharmaceutics; galenisk farmaci;

    Abstract : Simple gel formulations may be applied to enhance the systemic and local exposure of potential compounds. The aim of this thesis is the development and characterization of controlled release formulations based on thermo-reversible poloxamer gels, which are suitable for novel drug delivery applications. READ MORE

  4. 4. The wild male mink as a sentinel for endocrine-disrupting chemicals and reproductive toxicity

    University dissertation from ; Department of Clinical Sciences, Swedish University of Agricultural Sciences

    Author : Sara Persson; Sveriges lantbruksuniversitet.; [2013]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES;

    Abstract : Increasing evidence indicates that pollutants may affect the hormone system of humans and wildlife. These endocrine-disrupting chemicals are related to an increased risk of a variety of diseases and disorders, including adverse effects on the reproductive system. READ MORE

  5. 5. Molecular Mechanisms of Resin Acids and Their Derivatives on the Opening of a Potassium Channel

    University dissertation from Linköping : Linköping University Electronic Press

    Author : Nina Ottosson; Fredrik Elinder; David Engblom; Bertil Hille; [2017]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Voltage-gated ion channels play fundamental roles in excitable cells, such as neurons, where they enable electric signaling. Normally, this signaling is well controlled, but brain damage, alterations in the ionic composition of the extracellular solution, or dysfunctional ion channels can increase the electrical excitability thereby causing epilepsy. READ MORE