Search for dissertations about: "Kp"

Showing result 1 - 5 of 26 swedish dissertations containing the word Kp.

  2. 1. Physiologically Based Pharmacometric Models for Colistin and the Immune Response to Bacterial Infection

    Author : Salim Bouchene; Mats O. Karlsson; Wilhelm Huisinga; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PBPK model; endotoxin; colistin; WBPBPK-PD; CMS; inflammation; tissue distribution; Kp; predictions in tissue; interspecies scaling;

    Abstract : Antibiotic treatment failure might be due to bacterial resistance or suboptimal exposure at target site and there is a lack of knowledge on the interaction between antimicrobial pharmacodynamics (PD) and the immune response to bacterial infections. Therefore, it is crucial to develop tools to increase the understanding of drug disposition to better evaluate antibiotic candidates in drug development and to elucidate the role of the immune system in bacterial infections. READ MORE

  4. 2. Immunometabolic network interactions of the kynurenine pathway in cutaneous malignant melanoma

    Author : Soudabeh Rad Pour; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cancer is the second leading cause of mortality worldwide, and melanoma represents the most aggressive and deadliest form of skin cancer. Despite the various therapeutic approaches, metastatic melanoma is a disease with a poor prognosis. READ MORE

  5. 3. Advocates and Voices. Swedish patient associations, their importance to individuals with cancer and collaboration with health care

    Author : Christina Carlsson; Bröstcancer-genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; support; Patient associations; voluntary action perspective; cancer; membership; contact person; network; Cytologi; cancerology; oncology; Cytology; experiential knowledge; advocates; consumers involvement; voice of medicine; onkologi; voice of lifeworld;

    Abstract : Patient associations (PAs) have an increasing impact for their members and for the health care system. This thesis studies PAs for cancer patients (PACPs) ? currently with over 20 000 members in Sweden ? regarding coverage, activities, and collaboration with the health care system with specific reference to the members? experiences. READ MORE

  6. 4. Every bug counts : neonatal colonization and infection of Gram-negative bacilli : aspects on antibiotic resistance in Sweden and Ecuador

    Author : Viveka Nordberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Neonatal infections caused by extended-spectrum beta-lactamase (ESBL)-producing Gramnegative bacilli are associated with high morbidity and mortality. In order to perform targeted preventive interventions against the impacts of antibiotic resistance in neonates, it is crucial to study colonization, infection and the spread of EPE-bacteria. READ MORE

  7. 5. Mechanisms of inter-organ crosstalk mediated by tryptophan metabolism

    Author : Paula Sofia Valente da Silva; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Physical exercise and nutrition balance the “energy in-energy out” equilibrium that keeps the system at a dynamic homeostasis, energetically speaking. However, this is a simplistic vision of a dynamic system that is in a constant fine-tuning of all of its parts. READ MORE