Search for dissertations about: "Kristina Melkersson"

Found 2 swedish dissertations containing the words Kristina Melkersson.

2. 1. Influence of antipsychotic drugs on hormone levels

   Author : Kristina Melkersson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : antipsychotic agents; prolactin; growth hormone; insulin-like growth factor 1; insulin; leptin; lipids; side effects; weight gain; metabolic syndrome;

   Abstract : The aim of the studies summarized in this thesis was to investigate the influence of antipsychotic drugs on hormone levels, in order to identify causes of hormonally related side effects of these drugs. The effect of antipsychotics on the prolactin (PRL) secretion, the growth hormone (GH)-insulin-like growth factor I (IGF-I) axis and the glucose-insulin homeostasis was studied. READ MORE

4. 2. Pharmacogenetics and Antipsychotic Treatment in Schizophrenia with Special Focus on Adverse Drug Reactions

   Author : Arzu Gunes; Marja-Liisa Dahl; Maria Gabriella Scordo; Kristina I. Melkersson; Jürgen Brockmöller; Uppsala universitet; []
   Keywords : Medicine; Pharmacogenetics; schizophrenia; antipsychotic treatment; adverse effects; clinical outcome; Medicin;

   Abstract : Genetically determined differences in drug metabolism and disposition and drug targets play a pivotal role in the interindividual variability in the clinical outcome of antipsychotic treatment. The aim of this thesis was to study the impact of polymorphisms in genes involved in the pharmacokinetics and pharmacodynamics of antipsychotics, with special focus on their extrapyramidal and metabolic adverse effects. READ MORE