Search for dissertations about: "Ku86"

Found 5 swedish dissertations containing the word Ku86.

  2. 1. DNA-dependent protein kinase in human cells

    Author : Annahita Sallmyr; Malmö Klinisk mikrobiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; enzymology; virology; mycology; mykologi; virologi; Proteiner; enzymologi; bacteriology; Microbiology; Sjögren s syndrome; HL60; PMN; Ku86v; Ku86; DNA-PK; DNA DSBs; NHEJ; Proteins; Mikrobiologi; bakteriologi;

    Abstract : DNA-dependent protein kinase (DNA-PK) is a holoenzyme consisting of a regulatory subunit, the heterodimeric Ku70/86, and a catalytic subunit known as DNA-dependent protein kinase catalytic subunit (DNA-PKcs). DNA-PK takes part in a number of cellular functions including growth control, immunoglobulin gene rearrangement and DNA repair. READ MORE

  4. 2. Factors of importance for radiosensitivity of tonsillar carcinoma

    Author : Signe Friesland; Karolinska Institutet; Karolinska Institutet; []
    Keywords : TC; radiotherapy; radiosensitivity; complete remission; HPV; P53; MDM2; DNA-PK; DNA-PKcs; Ku86; Ku70.;

    Abstract : Radiotherapy (RT) alone or in combination with surgery is the only curative treatment of tonsillar carcinoma (TC). As distant metastases are rare the loco-regional control is the most important factor determining survival. Methods for prediction of radiocurability are lacking. READ MORE

  5. 3. Chemical, pharmacokinetic and biological aspects of platinum-based drugs

    Author : Jeffrey R Yachnin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The use of cisplatin for the treatment of metastatic testicular cancer is a medical historical landmark given that, for the first time, patients could be cured with drug therapy. A third generation platinum-based drug, oxaliplatin, has been registered for use in the treatment of colorectal cancer. READ MORE

  6. 4. Outcome of preoperative radiotherapy in the treatment of cervical cancer with focus on protein expression and dosimetry

    Author : Catharina Beskow; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Treatment with preoperative intracavitary radiotherapy (ICRT) is used in cervical cancer with the intention to reduce the tumour burden and sterilize microscopic disease in the paracervical tissues. Preoperative ICRT is, however, a controversial treatment regime since it is unclear if addition of ICRT to surgery improves treatment outcome compared to surgery alone. READ MORE

  7. 5. The use of IGF-IR inhibitors in cancer therapy : a potential approach for sensitizing tumor cells to ionizing radiation

    Author : Daria Cosaceanu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : This study focused on insulin-like growth factor I receptor (IGF-IR), considered as a promising therapeutic target for cancer treatment. We were in particular interested in the involvement of IGF-IR in tumor cells response to radiation and we tried to provide the rationale for a combined therapy of IFG4R inhibitors with radiation in order to improve the therapeutic outcome. READ MORE