Search for dissertations about: "Kukkonen Jyrki"

Found 5 swedish dissertations containing the words Kukkonen Jyrki.

  2. 1. Orexin Receptors in Recombinant CHO Cells : Signaling to Short- and Long-Term Cell Responses

    Author : Sylwia Ammoun; Jyrki Kukkonen; Karl Åkerman; Gunnar Flemström; Christer Larsson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; orexins; cell signaling; Neurovetenskap; Neurology; Neurologi;

    Abstract : Recently discovered neuropeptides orexins (orexin-A and -B) act as endogenous ligands for G-protein-coupled receptors called OX1 and OX2 receptors. Our previous studies have established model systems for investigation of the pharmacology and signaling of these receptors in recombinant CHO cells. READ MORE

  4. 2. OX1 Orexin Receptor Signalling to Phospholipases

    Author : Marie Ekholm; Jyrki Kukkonen; Graeme Milligan; Uppsala universitet; []
    Keywords : orexin; phospholipase; Calcium; cell signalling; G protein coupled receptor; ERK; live-cell imaging; arachidonic acid; diacylglycerol;

    Abstract : The neuropeptides orexin-A and orexin-B were discovered in 1998 and were first described as regulators of feeding behaviour. Later research has shown that they have an important role in the regulation of sleep. Two G protein-coupled receptors, OX1 and OX2 orexin receptors, mediate the cellular responses to orexins. READ MORE

  5. 3. Signaling via Orexin Receptors : A Pharmacological Study

    Author : Tomas Holmqvist; Jyrki Kukkonen; Karl Åkerman; Gunnar Flemström; Per Svenningsson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Physiology; orexin; receptors; calcium; cAMP; adenylyl cyclases; Fysiologi; Physiology; Fysiologi;

    Abstract : The orexin receptors are a pair of newly discovered G-protein coupled receptors which are activated by the neuropeptides orexins and play a role in sleep/vigilance, apetite/metabolism and neuroendocrine regulation. On a cellular level receptor activation results in, to name but a few effects, elevation of intracellular calcium and depolarisation. READ MORE

  6. 4. Calcium and Phospholipases in Orexin Receptor Signaling

    Author : Lisa Johansson; Jyrki Kukkonen; Karl Åkerman; Christopher S. Leonard; Uppsala universitet; []
    Keywords : Physiology; orexin; receptor; calcium; phospholipase; cell signaling; GPCR; Fysiologi;

    Abstract : The neuropeptides orexin-A and -B act as endogenous ligands for G-protein-coupled receptors (GPCRs) called OX1 and OX2 receptors. Previous observations have established that orexin receptors have an ability to couple to different G-proteins and signaling pathways and induce Ca2+ elevations via both receptor-operated Ca2+ channels (ROCs) and store-operated Ca2+ channels (SOCs). READ MORE

  7. 5. Investigation on Pre- and Postsynaptic Ca2+ Signaling in Neuronal Model Systems

    Author : Jelena Krjukova; Åkerman Karl; Kukkonen Jyrki; Rydqvist Bo; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Physiology; calcium; neurotransmitter release; nicotine; depolarization; G-protein coupled receptor; muscarinic; phospholipase C; m-3M3FBS; Fysiologi; Physiology; Fysiologi;

    Abstract : Communication between neuronal and non-neuronal is called volume transmission when the released neurotransmitter (NT) acts via diffusion and affects several target cells. Both the neurosecretory and postsynaptic cell responses are linked to [Ca2+]i elevations. READ MORE