Search for dissertations about: "L Wide"

Showing result 1 - 5 of 168 swedish dissertations containing the words L Wide.

  2. 1. Functional association networks for disease gene prediction

    Author : Dimitri Guala; Erik L L Sonnhammer; Hjalmar Brismar; Yves Moreau; Stockholms universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; network biology; biological networks; network prediction; functional association; functional coupling; network integration; functional association networks; genome-wide association networks; gene networks; protein networks; fret; functional enrichment analysis; network cross-talk; pathway annotation; gene prioritisation; network-based gene prioritization; benchmarking; Biochemistry towards Bioinformatics; biokemi med inriktning mot bioinformatik;

    Abstract : Mapping of the human genome has been instrumental in understanding diseasescaused by changes in single genes. However, disease mechanisms involvingmultiple genes have proven to be much more elusive. Their complexityemerges from interactions of intracellular molecules and makes them immuneto the traditional reductionist approach. READ MORE

  4. 2. Inference of functional association networks and gene orthology

    Author : Thomas Schmitt; Erik L. L. Sonnhammer; Søren Brunak; Stockholms universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; orthology; InParanoid; FunCoup; systems biology; biological networks; network inference; functional coupling; functional association; biokemi; inriktning teoretisk kemi; Biochemistry with Emphasis on Theoretical Chemistry;

    Abstract : Most proteomics and genomics experiments are performed on a small set of well-studied model organisms and their results are generalized to other species. This is possible because all species are evolutionarily related. When transferring information across species, orthologs are the most likely candidates for functional equivalence. READ MORE

  5. 3. Supra-threshold hearing loss and wide dynamic range compression

    Author : Henrik L. Olsen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Hearing impairment; compression; hearing aids; modulated noise; speech intelligibility; temporal resolution; modulation transfer function;

    Abstract : Cochlear hearing loss leads to deficits in many perceptual aspects, including threshold elevation (loss of sensitivity), reduction of auditory dynamic range (loudness recruitment) and problems with resolving sounds (loss of supra-threshold hearing). An ongoing debate is whether assessment of the individual supra-threshold hearing provides information which is likely to have an important influence on clinical decisions on signal processing strategies. READ MORE

  6. 4. Control Aspects of Complex Hydromechanical Transmissions : with a Focus on Displacement Control

    Author : L. Viktor Larsson; Petter Krus; Björn Eriksson; Linköpings universitet; []
    Keywords : ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; NATURAL SCIENCES; NATURVETENSKAP; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; NATURVETENSKAP; TEKNIK OCH TEKNOLOGIER; TEKNIK OCH TEKNOLOGIER; NATURAL SCIENCES; ENGINEERING AND TECHNOLOGY; ENGINEERING AND TECHNOLOGY;

    Abstract : This thesis deals with control aspects of complex hydromechanical transmissions. The overall purpose is to increase the knowledge of important aspects to consider during the development of hydromechanical transmissions to ensure transmission functionality. READ MORE

  7. 5. Molecular investigation of mucopolysaccharidosis type II (Hunter syndrome) in man

    Author : Stanislav L. Karsten; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; mucopolysaccharidosis type II; Hunter syndrome; MPSII; iduronate-2-sulfatase; mutational analysis; homologous nonhomologous recombination; Genetik; Clinical genetics; Klinisk genetik; Medical Genetics; medicinsk genetik;

    Abstract : Mucopolysaccharidosis type II or Hunter syndrome is a rare lysosomal storage disorder caused by a deficiency in the enzyme iduronate-2-sulfatase (IDS). The disorder is inherited in an X-linked recessive fashion and has a broad spectrum of clinical phenotypes ranging from severe to mild. READ MORE