Search for dissertations about: "L1 mRNA"

Showing result 11 - 15 of 31 swedish dissertations containing the words L1 mRNA.

  2. 11. Regulation of Human Papillomavirus Type 16 mRNA Splicing and Polyadenylation

    Author : Xiaomin Zhao; Stefan Schwartz; Barklie Clements; Uppsala universitet; []
    Keywords : Medical sciences; human papillomavirus type 16; gene regulation; splicing; polyadenylation; 3 UTR; MEDICIN OCH VÅRD; MEDICINE; MEDICIN;

    Abstract : Human papillomavirus type 16 (HPV-16) is the major causative agent of cervical cancer. The life cycle of this oncogenic DNA tumour virus is strictly associated with the differentiation program of the infected epithelial cells. Expression of the viral capsid genes L1 and L2 can only be detected in the terminally differentiated epithelial cells. READ MORE

  4. 12. The balance of splicing : A novel insight into the splicing regulation of high-risk HPV E6 and E7 oncogenes

    Author : Johanna Jönsson; Naoko Kajitani; Stefan Schwartz; Ola Forslund; Francesca Aguilo; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; HPV; splice donor; splice acceptor; cis-element; trans-acting factor; pre-mRNA splicing; splicing regulation.; Medical Virology; Medicinsk virologi;

    Abstract : HPV is associated with several cancers. The genome consists of a long control region, early (E1, E2, E4, E5, E6 and E7) and late (L1 and L2) genes. The E6 and E7 proteins prevent cells from entering apoptosis and regulate the cell cycle. A deregulated expression of these can result in malignant transformations. READ MORE

  5. 13. Tumor-infiltrating lymphocytes and the PD-L1/PD-1 signaling axis in breast cancer : biology and clinical implications

    Author : Ioannis Zerdes; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cancer immunotherapy and especially immune checkpoint blockade therapy has revolutionized cancer treatment in many tumor types including breast cancer (BC). The expression and specific role of Programmed Death-1 (PD-1)/Programmed Death-Ligand 1 (PD-L1) signaling axis, immune-related gene signatures and immune cell subpopulations needs to be fully elucidated while the identification of prognostic and predictive biomarkers in BC is of utmost importance. READ MORE

  6. 14. The Regulation of Human Papillomavirus Type16 Early Gene Expression

    Author : Xiaoxu Cui; Avdelningen för medicinsk mikrobiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Human papillomavirus; splicing; hnRNP D; m6A; LCR;

    Abstract : AbstractHuman papillomaviruses (HPVs) are small non enveloped viruses that contain a double-stranded circular DNA genome of approximately 8kb in size. It has been estimated that approximately 5% of all cancers are caused by HPV infection. Cervical cancer represents the majority of HPV-associated anogenital cancers worldwide. READ MORE

  7. 15. Functional Characterization of the Evolutionarily Conserved Adenoviral Proteins L4-22K and L4-33K

    Author : Sara Östberg; Göran Akusjärvi; Stefan Schwartz; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; L4-22K; L4-33K; RNA; splicing; adenovirus; nuclear localization; replication; transcription; evolution; SR protein; MLP; promoter; E1A; serotypes;

    Abstract : Regulation of adenoviral gene expression is a complex process directed by viral proteins controlling a multitude of different activities at distinct phases of the virus life cycle. This thesis discusses adenoviral regulation of transcription and splicing by two proteins expressed at the late phase: L4-22K and L4-33K. READ MORE