Search for dissertations about: "LCMV"

Showing result 1 - 5 of 6 swedish dissertations containing the word LCMV.

  2. 1. Hsp70 in immunotherapy : a potential vector in cancer and viral vaccines

    Author : Anne-Marie T Ciupitu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : heat shock protein 70; vaccination; tumour antigens; in vivo protection; T cell activation; adjuvant; LCMV;

    Abstract : New efficient vaccines against cancers and infectious diseases are in demand. In 1993 heat shock protein 70 (hsp70) purified from tumour was shown to elicit tumour protection in mice. It was also shown that the protection was not mediated by the hsp70 itself, but by tumour-specific peptides bound to the molecule. READ MORE

  4. 2. Enhancing T cell mediated immunity in DNA vaccination

    Author : Jan Alvar Lindencrona; Karolinska Institutet; Karolinska Institutet; []
    Keywords : DNA vaccination; CTL; T cell; IFN-gamma; anti-tumor immunity; HER-2 neu; Influenza; LCMV; Virus-Like Particles; murine models; adjuvants; immunotherapy;

    Abstract : For centuries infectious diseases have been one of the main causes of death in the world. With the invention of vaccine technology 200 years ago, we have been able to impede and even eradicate several dangerous pathogens. READ MORE

  5. 3. Structural insights into glycoprotein transport and viral escape

    Author : Lucas Malard Velloso; Karolinska Institutet; Karolinska Institutet; []
    Keywords : X-ray crystallography; glycoprotein transport; endoplasmic reticulum; p58 ERGIC-53; MHC class I molecules; viral escape;

    Abstract : The correct trafficking of proteins through the secretory pathway is essential for the maintenance of cellular functions. Increasing evidence suggests that at least for some glycoproteins, export from the endoplasmic reticulum (ER) is mediated by interaction with cargo receptors. READ MORE

  6. 4. Molecular basis for enhanced T-cell recognition and cross-reactivity

    Author : Eva Allerbring; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : T cells of the adaptive immune system recognize and kill infected cells by interacting with pathogenic peptides displayed on major histocompatibility complexes (MHC) through its T-cell receptor (TCR). TCR interactions with peptide/MHC complexes occur throughout the lifespan of T cells, from development to activation, with the origin of the peptide varying between self and foreign. READ MORE

  7. 5. Structural studies of MHC class 1 complexes : implications for NK- and T-cell recognition

    Author : Adnane Achour; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Crystallography; MHC class I molecules; MHC class I tetramers; NK cells; T cells;

    Abstract : The cell-cell recognition events and the functional characteristics of the cell surface receptors that govern the responses of NK- and T-cells are central to molecular immunology. This thesis addresses the structural basis of such molecular recognition, more specifically the interaction between peptides and MHC class I molecules, as well as the interaction between such complexes and the inhibitory Ly49 receptors of NK cells or triggering antigen specific receptors of T-cells (TCR). READ MORE