Search for dissertations about: "LDL binding"

Showing result 1 - 5 of 51 swedish dissertations containing the words LDL binding.

  2. 1. Atherogenic lipoproteins and their interaction with proteoglycans

    Author : Christofer Flood; Göteborgs universitet; []
    Keywords : apolipoprotein B; atherosclerosis; LDL; proteoglycan; sPLA2; ; retention;

    Abstract : Atherosclerosis is a multi-factorial disease and its pathogenesis is still unclear. However, accumulating evidence during recent years has led to the concept that subendothelial retention of atherogenic lipoproteins is the initiating event in atherogenesis. READ MORE

  4. 2. Lipoprotein(a) in cardiovascular disease

    Author : Ulf Lundstam; Göteborgs universitet; []
    Keywords : atherosclerosis; Lipoprotein a ; LDL; extracellular matrix; women;

    Abstract : The atherosclerotic process is continuous and starts early in life. Risk factors for atherosclerosis include hyperlipidemia, hypertension, smoking and diabetes mellitus. Fatty streaks characterised by lipid-laden macrophages are early signs of atherosclerosis. READ MORE

  5. 3. Retention of atherogenic lipoproteins in atherogenesis

    Author : Maria Gustafsson; Göteborgs universitet; []
    Keywords : apolipoprotein B; atherosclerosis; LDL; LpL; proteoglycans; retention; sPLA2;

    Abstract : Atherosclerosis is the most common cause of death in the industrialized world. The diseaseis characterized by lipid accumulation and inflammation in the arterial wall, which may leadto obstruction of the blood flow. READ MORE

  6. 4. Biomolecules at Interfaces -Studied by Surface and Solution Techniques

    Author : Anna Bergstrand; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; LDL; sepsis; PEG; LPS; lipopolysaccharide; QCM-D; SPR;

    Abstract : The interfacial behaviour of biomolecules in general and proteins in particular is interesting from a biochemical point of view since proteins are involved in processes such as complement activation, blood coagulation and atherosclerotic plaque formation, but also in the context of biomedical applications such as solid-phase diagnostics, therapeutic aphaeresis and biosensors. The objective of this thesis is to study biomolecular interactions using surface sensitive biosensor techniques such as surface plasmon resonance, SPR, in combination with bulk techniques. READ MORE

  7. 5. The effect of hypoxia on macrophage proteoglycans: potential role in atherosclerosis

    Author : Annika Asplund; Göteborgs universitet; []
    Keywords : atherosclerosis; proteoglycans; glycosaminoglycans; macrophages; hypoxia; hypoxia-inducible transcription factor; LDL binding; cell motility;

    Abstract : A critical step in the development of atherosclerotic lesions appears to be the retention of low density lipoproteins (LDL) in the arterial wall, mediated by negatively charged proteoglycans (PG). Retained LDL is susceptible to modification and uptake by resident macrophages that are found in hypoxic sites in atherosclerotic lesions (with oxygen levels below 1%). READ MORE