Search for dissertations about: "LL-37"

Showing result 1 - 5 of 64 swedish dissertations containing the word LL-37.

  2. 1. LL-37-derived cyclic antimicrobial drug leads : Design, synthesis, activity and different ways of creating them 

    Author : Taj Muhammad; Ulf Göransson; Sunithi Gunasekera; Adam A. Strömstedt; Wang Guangshun; Uppsala universitet; []
    Keywords : antimicrobial peptide; host defense; antimicrobial; LL-37; KR-12; peptide cyclisation; peptide dimerisation; croos-linking; cyanobactin-macrocyclase; PatGmac; butelase 1; enzymatic cyclisation; immobilisation; Farmakognosi; Pharmacognosy;

    Abstract : In an era where last-line antibiotics are failing, one of the powerful approaches to develop novel therapeutic agents is to turn back to nature in order to identify possible drug candidates. Among the potential candidates, antimicrobial peptides (AMPs) have garnered much attention as an antimicrobial. READ MORE

  4. 2. Effects of the host defense peptide LL-37 on human cells : Immunomodulation and cytotoxicity

    Author : Sara Bodahl; Kärlfysiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LL-37; Host defense peptides; Cathelicidin; Inflammation; Cytotoxicity; TLR3; Poly I:C;

    Abstract : The human host defense peptide LL-37 has an essential role in the first line of defense against invading pathogens. This cathelicidin is mainly produced by immune cells and epithelial cells aligning the mucosal areas and is normally upregulated upon infection and inflammation. READ MORE

  5. 3. Saliva: a cell suspension of epithelial cells harboring the antimicrobial peptide LL-37 and the growth factor EGF

    Author : Alexandra Aidoukovitch; Institutionen för experimentell medicinsk vetenskap; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Saliva; Oral health; Innate immunity; Cathelicidin; LL-37; Host defense peptides; EGF; Saliva; Oral health; Innate immunity; Cathelicidin; LL-37; Host defence peptides; EGF;

    Abstract : Saliva plays a crucial role in maintaining oral health through its physical and chemical properties that provide various protective functions. One of its essential components is the human host defense peptide LL-37, which is produced by immune cells and epithelial cells, and participates in the first line of defense against pathogens. READ MORE

  6. 4. Regulation of human cell viability by the host defence peptide LL-37

    Author : Daniel Svensson; Kärlfysiologi; []
    Keywords : LL-37; cathelicidin; cytotoxicity; host defence peptides; autoimmune diseases; inflammation; vitamin D;

    Abstract : Accumulating evidence suggests that the main human cathelicidin peptide, LL-37, may influence host cell viability and pro-inflammatory signaling when locally overexpressed. LL-37 has pro-inflammatory properties linked to the development of for example psoriasis, rosacea, SLE and atherosclerosis. READ MORE

  7. 5. Functional dualism of antimicrobial host defence peptides

    Author : Åse Björstad; Göteborgs universitet; []
    Keywords : antimicrobial; apoptosis; cathelicidin; host defence peptide; interleukin 8; LL-37; permeabilisation;

    Abstract : Antimicrobial host defence peptides are central to innate immunity and many possess direct antimicrobial actions on bacteria as well as indirect immunomodulatory functions on human leukocytes. Different variants of the bifunctional Helicobacter pylori peptide, Hp(2-20), were synthesised and inhibition zone assays and chemiluminescence systems were employed for determination of direct antimicrobial action and superoxide release (immunomodulatory) from human neutrophils, respectively. READ MORE