Search for dissertations about: "LMX1A"

Showing result 1 - 5 of 10 swedish dissertations containing the word LMX1A.

  2. 1. On the influence of dopamine-related genetic variation on dopamine-related disorders

    Author : Olle Bergman; Göteborgs universitet; []
    Keywords : dopamine; neurodevelopment; amygdala; schizophrenia; Parkinson s disease; social anxiety disorder; ADHD; PITX3; LMX1A; LMX1B; BDNF; DAT; SNP; genes; genetics; BDNF;

    Abstract : Rationale: Dopamine synthesizing neurons are involved in a wide variety of functions. The most prominent dopamine pathways originate in the midbrain. The development, function and survival of these dopaminergic neurons are under the influence of numerous transcription and neurotrophic factors. READ MORE

  4. 2. The role of Lmx1a and Lmx1b in regulating mesencephalon development and dopamine neuron specification

    Author : Qiaolin Deng; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : One of the most challenging questions in developmental biology is how neurons are specified, acquire their distinct characteristics and find their correct innervations to form functional circuits. The development of different subsets of neurons involves the expression of a program intrinsic to each cell type and the response to extrinsic environmental influences represented by soluble factors. READ MORE

  5. 3. Generation of dopamine neurons in vivo and from embryonic stem cells in vitro

    Author : Stina Friling; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Mesencephalic dopamine (mesDA) neurons degenerate in patients with Parkinson s disease. In order to develop new treatment strategies for rescuing or replacing degenerating mesDA neurons, an improved understanding of the development and survival of these neurons in the normal brain is required. READ MORE

  6. 4. Progressive models of Parkinson's disease : behavioural and neurochemical analyses

    Author : Alexandra Alvarsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Parkinson’s disease (PD) is a common neurodegenerative disorder diagnosed based on the presence of motor symptoms, including resting tremor, postural impairment, bradykinesia and rigidity. The pathological hallmarks are degeneration of midbrain dopaminergic neurons and the accumulation of inclusions containing the misfolded protein α-synuclein (termed “Lewy bodies”) throughout the nervous system. READ MORE

  7. 5. Resolving developing neuronal lineages in the ventral midbrain

    Author : Nigel Kee; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The numerous cells and cell types of our bodies originate from a fertilised egg. Through the study of the developing embryo, we have come to understand much about how different cells in different tissues arise from this single cell, and how they are related to one another within an expansive family tree. READ MORE