Search for dissertations about: "LOH."

Showing result 1 - 5 of 56 swedish dissertations containing the word LOH..

  2. 1. RNA-mediated virulence gene regulation in the human pathogen Listeria monocytogenes

    Author : Edmund Loh; Jörgen Johansson; Nancy Freitag; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Listeria monocytogenes; virulence; ncRNAs; PrfA; 5´-UTRs; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Abstract : The Gram-positive human pathogen Listeria monocytogenes uses a wide range of virulence factors for its pathogenesis. The majority of its virulence genes are encoded on a 9-kb pathogenicity island and are controlled by the transcriptional activator PrfA. READ MORE

  4. 2. Exploring genomic and phenotypic differences in Neisseria meningitidis – understanding carriage and invasive disease

    Author : Lorraine Eriksson; Paula Mölling; Edmund Loh; Örebro universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : .... READ MORE

  5. 3. Genetic studies of endocrine abdominal tumors

    Author : Ola Hessman; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; MEN1; LOH; pancreatic endocrine tumors; midgut carcinoid; Smad4 DPC4; Kirurgi; Surgery; Kirurgi; Surgery; kirurgi;

    Abstract : Pancreatic endocrine tumors (PETs) occur sporadically or in the familial multiple endocrine neoplasia type 1 (MEN1) syndrome, whereas midgut carcinoids are nonfamilial, malignant endocrine tumors of the intestine. For these tumor entities morphological criteria are of limited use for prognostic prediction and selection of treatment. READ MORE

  6. 4. Molecular Pathogenesis of Cervical Carcinoma : Analysis of Clonality, HPV16 Sequence Variations and Loss of Heterozygosity

    Author : Xinrong Hu; Björn Hagmar; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; cervical carcinoma; CIN; HPV; LOH; X-chromosome inactivation; clonality; molecular pathogenesis; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

    Abstract : A previous model of morphological pathogenesis assumed that cervical carcinoma is of monoclonal origin and progresses through multiple steps from normal epithelium via CINS into invasive carcinomas. The aim of this study was to investigate the molecular mechanism of pathogenesis of cervical neoplasia. READ MORE

  7. 5. Hereditary Breast Cancer in South Sweden. Early findings from studies on the role of BRCA1

    Author : Oskar Thor Johannsson; Bröstcancer-genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; survival analysis; CGH; mRNA in situ hybridization; germline mutations; LOH; Breast neoplasm; BRCA1; Cytology; oncology; cancerology; Cytologi; onkologi; cancer;

    Abstract : The thesis presents the results from investigations into the role of BRCA1 in hereditary cancer in South Sweden. Loss of heterozygosity (LOH) studies found loss of the wildtype allele of BRCA1 to be common in BRCA1 associated breast cancer, but due to the high degree of LOH on chr. READ MORE