Search for dissertations about: "LRH-1"

Showing result 1 - 5 of 6 swedish dissertations containing the word LRH-1.

  1. 1. Developmental and reproductive regulation of NR5A genes in teleosts

    Author : Jonas von Hofsten; Per-Erik Olsson; Gregory Kelly; Umeå universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; FTZ-F1; NR5A; zebrafish; teleost; arctic char; SF-1; LRH-1; fushi tarazu; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi; molekylärbiologi; Molecular Biology;

    Abstract : In mammals sex chromosomes direct and initiate the development of male and female gonads and subsequently secondary sex characteristics. In most vertebrates each individual is pre-destined to either become male or female. READ MORE

  2. 2. Transcriptional Regulation by the Nuclear Receptors Steroidogenic Factor-1 and Liver Receptor Homologue-1

    Author : Anna Ehrlund; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : Steroidogenic Factor-1 (SF-1) and Liver Receptor Homologue-1 (LRH-1) are transcription factors belonging to the nuclear receptor (NR) family. In the adrenal cortex and gonads, SF-1 governs the expression of multiple enzymes and transporters required for converting cholesterol to steroid hormones. READ MORE

  3. 3. Molecular mechanisms of transcriptional repression by the orphan receptor SHP

    Author : Ann Båvner; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Nuclear receptor; repression; small heterodimer partner; co-regulator;

    Abstract : SHP (Small Heterodimer Partner) is an atypical orphan member of the mammalian nuclear receptor family that consists of only a putative ligand-binding domain and thus cannot bind DNA. The aim of this thesis was to investigate the molecular mechanisms of the transcriptionally inhibitory effect of SHP. READ MORE

  4. 4. Molecular Dynamic Studies of Nuclear Receptors Ligand Binding Domain

    Author : Sofia Burendahl; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : Nuclear Receptors (NR) function as transcription factors that regulate genes that affect processes like reproduction, development and metabolism. The NRs are activated upon a given signal, which can be a ligand binding or a chemical modification. READ MORE

  5. 5. Oxysterol receptors LXRs and coregulators in cholesterol metabolism and inflammatory transrepression pathways

    Author : Tomas Jakobsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : The LXRs are important sensors and regulators of cholesterol homeostasis in several metabolic tissues including liver, intestine and macrophages. They regulate target genes involved in cholesterol-, lipid- and carbohydrat metabolism. READ MORE