Search for dissertations about: "LRIG1"

Showing result 1 - 5 of 10 swedish dissertations containing the word LRIG1.

  1. 1. Studies of LRIG1 and the ERBB receptor family in breast and colorectal cancer

    University dissertation from Umeå : Umeå universitet

    Author : Ingrid Ljuslinder; Umeå universitet.; Umeå universitet.; [2009]
    Keywords : breast cancer; colorectal cancer; LRIG1; EGFR; ERBB2; invasive margin; onkologi; Oncology;

    Abstract : The LRIG1 gene (leucine-rich repeats and immunoglobulin like domains-1) at chromosome 3p14 is a proposed tumour suppressor gene whose gene product negatively regulates various receptor tyrosine kinases. This function has been the basis for classifying LRIG1 as a potential tumour suppressor gene (TSG). READ MORE

  2. 2. Expression and prognostic value of LRIG1 and the EGF-receptor family in renal cell and prostate cancer

    University dissertation from Umeå : Umeå university

    Author : Marcus Thomasson; Umeå universitet.; [2009]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; Renal cell carcinoma; EGFR; ErbB1-4; LRIG1; MEDICINE Surgery Oncology; MEDICIN Kirurgi Onkologi; onkologi; Oncology;

    Abstract : The epidermal growth factor receptor (EGFR) family consists of four (EGFR, ErbB2, Erbb3, and ErbB4) receptor tyrosine kinases (RTK) whose signalling is important for physiological and malignant cellular functions such as proliferation, survival, migration, and differentiation. EGFR and ErbB2 in particular are established oncogenes in many solid tumours and are targets for anti-cancer treatment. READ MORE

  3. 3. Investigations of Leucine-rich repeats and immunoglobulin-like domain-proteins 1 and 2 (LRIG1 and LRIG2) and their genes in cancer

    University dissertation from Umeå : Umeå university

    Author : Mahmood Faraz; Umeå universitet.; [2018]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LRIG1; LRIG2; PDGFR; glioma; interactome; breast cancer; prognosis; onkologi; Oncology;

    Abstract : The mammalian leucine-rich repeats and immunoglobulin-like domains (LRIG) gene family consists of three different members, LRIG1, LRIG2, and LRIG3. These genes are expressed in all human and mouse tissues analyzed to date. READ MORE

  4. 4. The expression and molecular functions of LRIG proteins in cancer and psoriasis

    University dissertation from Umeå : Print och Media

    Author : Terese Karlsson; Umeå universitet.; [2013]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LRIG1; LRIG2; LRIG3; LMO7 lung cancer; glioma; psoriasis; onkologi; Oncology;

    Abstract : The leucine-rich repeats and immunoglobulin-like domains (LRIG) family consists of three integral membrane proteins that are important in human cancer. LRIG1 is a negative regulator of growth factor signaling. Its expression is associated with longer survival in several cancer types, and the gene has been shown to function as a tumor suppressor. READ MORE

  5. 5. Prognostic factors for squamous cell cervical cancer tumor markers, hormones, smoking, and S-phase fraction

    University dissertation from Umeå : Umeå university

    Author : Annika Lindström; Umeå universitet.; [2010]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICINE; MEDICIN; onkologi; Oncology; Cervical cancer; squamous cell carcinoma; sex steroid hormones; smoking; S-phase fraction; tumor markers; LRIG1; prognosis.;

    Abstract : Cervical cancer is the second most common malignancy in women worldwide and one of the leading causes of cancer mortality globally. In patients with invasive cervical cancer prognostic factors are of value for the choice of treatment, monitoring of treatment and follow-up. READ MORE